发明申请
- 专利标题: NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS
- 专利标题(中): 用于输送治疗药物的新型脂肪和组合物
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申请号: US13128283申请日: 2009-11-10
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公开(公告)号: US20110311582A1公开(公告)日: 2011-12-22
- 发明人: Muthiah Manoharan , Muthusamy Jayaraman , Kallanthottathil G. Rajeev , laxman Eltepu , Steven Ansell , Jianxin Chen
- 申请人: Muthiah Manoharan , Muthusamy Jayaraman , Kallanthottathil G. Rajeev , laxman Eltepu , Steven Ansell , Jianxin Chen
- 国际申请: PCT/US09/63927 WO 20091110
- 主分类号: A61K39/12
- IPC分类号: A61K39/12 ; C07D203/08 ; A61K47/44 ; A61K31/7088 ; A61K31/7105 ; A61K31/713 ; C12N5/071 ; C12N15/85 ; A61K39/00 ; A61K39/02 ; A61P37/04 ; A61P31/12 ; A61P31/04 ; A61P33/00 ; A61P35/00 ; C07C229/30
摘要:
The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention formula (I) provides lipids having the following structure XXXIII wherein: R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alky lhetro cycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; and E is C(O)O or OC(O).
公开/授权文献
- US09186325B2 Lipids and compositions for the delivery of therapeutics 公开/授权日:2015-11-17