发明申请
US20110313169A1 PROCESS FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE THROUGH COUPLING USING TRANSITION METAL CATALYST
有权
通过使用过渡金属催化剂的偶联生产苯基取代的杂环衍生物的方法
- 专利标题： PROCESS FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE THROUGH COUPLING USING TRANSITION METAL CATALYST
- 专利标题（中）： 通过使用过渡金属催化剂的偶联生产苯基取代的杂环衍生物的方法
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申请号： US13148820申请日： 2010-02-26
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公开(公告)号： US20110313169A1公开(公告)日： 2011-12-22
- 发明人: Masato Komiyama , Naoki Yajima , Masayuki Kurokawa
- 申请人： Masato Komiyama , Naoki Yajima , Masayuki Kurokawa
- 申请人地址： JP Chiyoda-ku, Tokyo
- 专利权人： TEIJIN PHARMA LIMITED
- 当前专利权人： TEIJIN PHARMA LIMITED
- 当前专利权人地址： JP Chiyoda-ku, Tokyo
- 优先权： JP2009-046003 20090227; JP2009-153770 20090629
- 国际申请： PCT/JP2010/053043 WO 20100226
- 主分类号： C07D277/56
- IPC分类号： C07D277/56
摘要：
A process for efficiently producing, through few steps either a xanthine oxidase inhibitor, which is a therapeutic agent for hyperuricemia, or an intermediate therefore. The process is a novel coupling process which comprises subjecting a compound represented by formula (1) to coupling reaction with a compound represented by formula (2) in the presence of a transition metal compound to thereby obtain a compound represented by formula (3).
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