发明申请
- 专利标题： BIOLOGIC COMPOUNDS
- 专利标题（中）： 生物化学物质
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申请号： US13024174申请日： 2011-02-09
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公开(公告)号： US20110318366A1公开(公告)日： 2011-12-29
- 发明人: Karen CROMIE , Bruno DOMBRECHT , Seth ETTENBERG , Joost KOLKMAN , Jing LI , Kris MEERSCHAERT , David Raymond STOVER , Jingxin ZHANG
- 申请人： Karen CROMIE , Bruno DOMBRECHT , Seth ETTENBERG , Joost KOLKMAN , Jing LI , Kris MEERSCHAERT , David Raymond STOVER , Jingxin ZHANG
- 申请人地址： BE Zwijnaarde CH Basel
- 专利权人： ABLYNX NV,NOVARTIS AG
- 当前专利权人： ABLYNX NV,NOVARTIS AG
- 当前专利权人地址： BE Zwijnaarde CH Basel
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61P35/00 ; A61P35/02 ; C07K16/28
摘要：
The present invention relates to amino acid sequences that are directed against TRAIL cell surface receptor 2 (herein also “DR5”), as well as to compounds or constructs thereof, and in particular proteins and polypeptides and nucleotides that encode them (referred to herein in their entirety as “NB agents”) and fragments thereof, and pharmaceutically effective variants thereof, and their use in the diagnosis and treatment of DR5 associated diseases and disorders.
公开/授权文献
- US09120855B2 Biologic compounds directed against death receptor 5 公开/授权日：2015-09-01