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公开(公告)号:US20110318366A1
公开(公告)日:2011-12-29
申请号:US13024174
申请日:2011-02-09
申请人: Karen CROMIE , Bruno DOMBRECHT , Seth ETTENBERG , Joost KOLKMAN , Jing LI , Kris MEERSCHAERT , David Raymond STOVER , Jingxin ZHANG
发明人: Karen CROMIE , Bruno DOMBRECHT , Seth ETTENBERG , Joost KOLKMAN , Jing LI , Kris MEERSCHAERT , David Raymond STOVER , Jingxin ZHANG
IPC分类号: A61K39/395 , A61P35/00 , A61P35/02 , C07K16/28
CPC分类号: C07K16/2878 , A61K2039/505 , C07K2316/95 , C07K2317/22 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要: The present invention relates to amino acid sequences that are directed against TRAIL cell surface receptor 2 (herein also “DR5”), as well as to compounds or constructs thereof, and in particular proteins and polypeptides and nucleotides that encode them (referred to herein in their entirety as “NB agents”) and fragments thereof, and pharmaceutically effective variants thereof, and their use in the diagnosis and treatment of DR5 associated diseases and disorders.
摘要翻译: 本发明涉及针对TRAIL细胞表面受体2(本文还称为“DR5”)的氨基酸序列以及编码它们的化合物或构建体,特别是编码它们的蛋白质和多肽和核苷酸(在本文中称为 其整体作为“NB剂”)及其片段及其药学上有效的变体,以及它们在诊断和治疗DR5相关疾病和病症中的用途。
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公开(公告)号:US20170101476A1
公开(公告)日:2017-04-13
申请号:US14751417
申请日:2015-06-26
申请人: Michelle BRADLEY , Zarin BROWN , Steven John CHARLTON , Karen CROMIE , Bruno DOMBRECHT , Soren STEFFENSEN , Gino Anselmus VAN HEEKE
发明人: Michelle BRADLEY , Zarin BROWN , Steven John CHARLTON , Karen CROMIE , Bruno DOMBRECHT , Soren STEFFENSEN , Gino Anselmus VAN HEEKE
IPC分类号: C07K16/28
CPC分类号: C07K16/2866 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/569 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.
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公开(公告)号:US20140050736A1
公开(公告)日:2014-02-20
申请号:US14065679
申请日:2013-10-29
申请人: Michelle BRADLEY , Zarin BROWN , Steven John CHARLTON , Karen CROMIE , Bruno DOMBRECHT , Soren STEFFENSEN , Gino Anselmus VAN HEEKE
发明人: Michelle BRADLEY , Zarin BROWN , Steven John CHARLTON , Karen CROMIE , Bruno DOMBRECHT , Soren STEFFENSEN , Gino Anselmus VAN HEEKE
IPC分类号: C07K16/28
CPC分类号: C07K16/2866 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/569 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.
摘要翻译: 本发明涉及针对或特异性结合趋化因子受体CXCR2的多肽,特别涉及能够调节CXCR2信号转导的多肽。 本发明还涉及能够表达本发明多肽的核酸,载体和宿主细胞,包含多肽的药物组合物以及用于治疗涉及CXCR2异常功能的疾病的所述多肽和组合物的用途。
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公开(公告)号:US20120183549A1
公开(公告)日:2012-07-19
申请号:US13290175
申请日:2011-11-07
申请人: Michelle BRADLEY , Zarin BROWN , Steven John CHARLTON , Karen CROMIE , Bruno DOMBRECHT , Soren STEFFENSEN , Gino VAN HEEKE
发明人: Michelle BRADLEY , Zarin BROWN , Steven John CHARLTON , Karen CROMIE , Bruno DOMBRECHT , Soren STEFFENSEN , Gino VAN HEEKE
IPC分类号: A61K39/395 , C12N15/62 , C12N15/63 , C07K19/00 , C12N15/13 , C12N1/21 , C12N1/19 , C12N5/10 , A61P11/00 , A61P11/06 , A61P9/10 , A61P13/12 , A61P1/00 , A61P9/00 , A61P27/02 , A61P9/12 , A61P29/00 , A61P19/02 , A61P35/00 , A61P35/04 , A61P7/00 , A61P3/10 , C07K16/46
CPC分类号: C07K16/2866 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/569 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.
摘要翻译: 本发明涉及针对或特异性结合趋化因子受体CXCR2的多肽,特别涉及能够调节CXCR2信号转导的多肽。 本发明还涉及能够表达本发明多肽的核酸,载体和宿主细胞,包含多肽的药物组合物以及用于治疗涉及CXCR2异常功能的疾病的所述多肽和组合物的用途。
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