发明申请
- 专利标题： Dominant Negative WNT2 Compositions and Methods of Use
- 专利标题（中）： 主要负WNT2组合物和使用方法
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申请号： US13142055申请日： 2009-12-30
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公开(公告)号： US20110319337A1公开(公告)日： 2011-12-29
- 发明人: Dawn Bravo , Liang You , Zhidong Xu , Biao He , David M. Jablons
- 申请人： Dawn Bravo , Liang You , Zhidong Xu , Biao He , David M. Jablons
- 国际申请： PCT/US09/69863 WO 20091230
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; C12N15/12 ; C12N15/63 ; C12N1/21 ; C07K19/00 ; C12N5/10 ; C12N5/09 ; G01N33/566 ; C12Q1/68 ; A61P35/00 ; C07K14/47 ; C12N1/19
摘要：
The present disclosure provides compositions, pharmaceutical preparations, kits and methods for inhibiting cell proliferation by contacting a cell expressing Fzd8 with a truncated Wnt2 polypeptide which acts as a dominant negative inhibitor of Fzd8 signaling. The present disclosure provides compositions, kits and methods for the detection of cancer by determining the level of Fzd8 and/or Wnt2 expression in a cell.
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