Invention Application
US20110319378A1 PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
有权
作为MDM2抑制剂治疗癌症的哌啶酮衍生物
- Patent Title: PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
- Patent Title (中): 作为MDM2抑制剂治疗癌症的哌啶酮衍生物
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Application No.: US13153345Application Date: 2011-06-03
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Publication No.: US20110319378A1Publication Date: 2011-12-29
- Inventor: Michael David BARTBERGER , Ana GONZALEZ BUENROSTRO , Hilary Plake BECK , Xiaoqi CHEN , Richard Victor CONNORS , Jeffrey DEIGNAN , Jason DUQUETTE , John EKSTEROWICZ , Benjamin FISHER , Brian Matthew FOX , Jiasheng FU , Zice FU , Felix GONZALEZ LOPEZ DE TURISO , Michael GRIBBLE, JR. , Darin James GUSTIN , Julie Anne HEATH , Xin HUANG , Xianyun JIAO , Michael G. JOHNSON , Frank KAYSER , David John KOPECKY , Sujen LAI , Yihong LI , Zhihong LI , Jiwen LIU , Jonathan Dante LOW , Brian Stuart LUCAS , Zhihua MA , Lawrence McGEE , Joel McINTOSH , Dustin McMINN , Julio Cesar MEDINA , Jeffrey Thomas MIHALIC , Steven Howard Olson , Yosup REW , Philip Marley ROVETO , Daqing SUN , Xiaodong WANG , Yingcai WANG , Xuelei YAN , Ming YU , Jiang ZHU
- Applicant: Michael David BARTBERGER , Ana GONZALEZ BUENROSTRO , Hilary Plake BECK , Xiaoqi CHEN , Richard Victor CONNORS , Jeffrey DEIGNAN , Jason DUQUETTE , John EKSTEROWICZ , Benjamin FISHER , Brian Matthew FOX , Jiasheng FU , Zice FU , Felix GONZALEZ LOPEZ DE TURISO , Michael GRIBBLE, JR. , Darin James GUSTIN , Julie Anne HEATH , Xin HUANG , Xianyun JIAO , Michael G. JOHNSON , Frank KAYSER , David John KOPECKY , Sujen LAI , Yihong LI , Zhihong LI , Jiwen LIU , Jonathan Dante LOW , Brian Stuart LUCAS , Zhihua MA , Lawrence McGEE , Joel McINTOSH , Dustin McMINN , Julio Cesar MEDINA , Jeffrey Thomas MIHALIC , Steven Howard Olson , Yosup REW , Philip Marley ROVETO , Daqing SUN , Xiaodong WANG , Yingcai WANG , Xuelei YAN , Ming YU , Jiang ZHU
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Main IPC: A61K31/451
- IPC: A61K31/451 ; C07D413/06 ; A61K31/5377 ; C07D401/06 ; A61K31/454 ; C07D417/06 ; A61K31/541 ; A61K31/4545 ; C07D413/12 ; C07D471/10 ; A61K31/438 ; C07D409/04 ; A61K31/4535 ; A61K31/496 ; C07D279/02 ; C07D498/08 ; A61K31/5386 ; A61K31/549 ; C07D498/16 ; A61K31/437 ; A61P35/00 ; C07D211/40
Abstract:
The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
Public/Granted literature
- US08569341B2 Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer Public/Granted day:2013-10-29
Information query
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