Invention Application
US20110319379A1 Substituted Indazole Amides And Their Use As Glucokinase Activators
审中-公开
取代的吲唑酰胺及其作为葡萄糖激酶的用途
- Patent Title: Substituted Indazole Amides And Their Use As Glucokinase Activators
- Patent Title (中): 取代的吲唑酰胺及其作为葡萄糖激酶的用途
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Application No.: US13255329Application Date: 2010-03-04
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Publication No.: US20110319379A1Publication Date: 2011-12-29
- Inventor: Jeffrey W. Corbett , Angel Guzman-Perez , Jeffrey A. Pfefferkorn , Meihua Tu
- Applicant: Jeffrey W. Corbett , Angel Guzman-Perez , Jeffrey A. Pfefferkorn , Meihua Tu
- International Application: PCT/IB2010/050944 WO 20100304
- Main IPC: A61K31/497
- IPC: A61K31/497 ; C07D403/14 ; A61K31/506 ; A61K31/4439 ; C07D403/12 ; A61K31/416 ; C07D401/12 ; C07D413/14 ; A61K31/5377 ; C07D417/12 ; A61K31/433 ; A61K31/4192 ; C07D409/14 ; A61P3/04 ; A61P3/10 ; C07D401/14
Abstract:
The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R4, R6, X, Y and Z are as defined herein. The compounds of Formula (I) have been found to act as glucokinase activators. Consequently, the compounds of Formula (I) and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucokinase.
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