发明申请
- 专利标题： siRNA targeting cyclin-dependent kinase 4 (CDK4)
- 专利标题（中）： siRNA靶向细胞周期蛋白依赖性激酶4（CDK4）
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申请号： US13199001申请日： 2011-08-17
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公开(公告)号： US20110319474A1公开(公告)日： 2011-12-29
- 发明人: Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
- 申请人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
- 申请人地址： US CO Lafayette
- 专利权人： DHARMACON, INC.
- 当前专利权人： DHARMACON, INC.
- 当前专利权人地址： US CO Lafayette
- 主分类号： A61K31/713
- IPC分类号： A61K31/713 ; C12N5/00 ; C07H21/02
摘要：
Efficient sequence specific gene silencing for cyclin-dependent kinase 4 is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.
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