Failing bus lane detection using syndrome analysis, including a method for receiving a plurality of syndromes of an error detection code, the error detection code associated with a plurality of frames that have been transmitted on a bus that includes a plurality of lanes and is protected by the error detection code. The method includes performing for each of the lanes in each of the syndromes: decoding the syndrome under an assumption that the lane is a failing lane, the decoding outputting a decode result; determining if the decode result is a valid decode; and voting for the lane in response to determining that the decode result is a valid decode. A failing lane is then identified in response to the voting, with the failing lane being characterized by having more votes than at least one other lane on the bus.