发明申请
- 专利标题: Quaternised Ammonium Cyclodextrin Compounds
- 专利标题(中): 季铵化环糊精化合物
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申请号: US13234912申请日: 2011-09-16
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公开(公告)号: US20120004158A1公开(公告)日: 2012-01-05
- 发明人: Georg Ludwig Kis , Christian Schoch , Jozsef Szejtli
- 申请人: Georg Ludwig Kis , Christian Schoch , Jozsef Szejtli
- 优先权: EP02013074.6 20020613; EP02028554.0 20021220
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; A61P31/04 ; A61K31/711 ; A61P31/10 ; A61K31/7105 ; A61K31/715 ; A61P31/00
摘要:
Use of a compound of formula (I): wherein the symbol cyclodextrin ]n represents a n-valent residue derived from a cyclodextrin compound by removing n of its hydroxyl groups; n is a number greater than 0 and represents the average number of substituents of formula per molecule of said compound; h is 0 or 1; R1 is a di-valent group selected from alkylene, hydroxy alkylene, halogeno alkylene, monocyclic aralkylene, cycloalkylene and phenylene; R2, R3 and R4 are each independently of one another a group selected from alkyl, cycloalkyl, aryl, aralkyl, and cycloheteryl; Xm− is a m-fold negatively charged anion; m is an integer being equal or greater than 1; and k is n/m in the preparation of an anti-infective medicament, as preservative and penetration enhancer.