Invention Application
- Patent Title: T CELL RECEPTOR AND NUCLEIC ACID ENCODING THE RECEPTOR
- Patent Title (中): T细胞受体和核酸编码受体
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Application No.: US13257389Application Date: 2010-04-02
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Publication No.: US20120009162A1Publication Date: 2012-01-12
- Inventor: Masaki Yasukawa , Hiroshi Fujiwara , Toshiki Ochi , Junichi Mineno , Ikunoshin Kato
- Applicant: Masaki Yasukawa , Hiroshi Fujiwara , Toshiki Ochi , Junichi Mineno , Ikunoshin Kato
- Priority: JP2009-091384 20090403
- International Application: PCT/JP2010/056089 WO 20100402
- Main IPC: A61K35/12
- IPC: A61K35/12 ; C12N15/63 ; A61P35/00 ; C07K14/435 ; C07H21/04 ; C12N5/10 ; A61K31/7088
Abstract:
Disclosed are: polypeptides for TCR α-chain and β-chain which are restricted to HLA-A*0201 for Aur-A and are derived from a CTL; and nucleic acids encoding the polypeptides. The nucleic acids can impart a cytotoxic activity against a cell capable of presenting an HLA-A*0201 molecule and an Aur-A207-215 peptide thereon to a T cell, and are therefore useful for the treatment of cancer in which Aur-A is expressed.
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