发明申请
US20120015440A1 SPHEROID COMPOSITE, SPHEROID-CONTAINING HYDROGEL AND PROCESSES FOR PRODUCTION OF SAME
审中-公开
SPHEROID COMPOSITE，含SPHEROID的水凝胶及其制造方法
- 专利标题： SPHEROID COMPOSITE, SPHEROID-CONTAINING HYDROGEL AND PROCESSES FOR PRODUCTION OF SAME
- 专利标题（中）： SPHEROID COMPOSITE，含SPHEROID的水凝胶及其制造方法
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申请号： US13060693申请日： 2009-09-08
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公开(公告)号： US20120015440A1公开(公告)日： 2012-01-19
- 发明人: Hidenori Otsuka , Tomomi Satomi , Koji Ueno , Masashi Yamamoto , Yuichi Nakasone , Kyoko Akashi
- 申请人： Hidenori Otsuka , Tomomi Satomi , Koji Ueno , Masashi Yamamoto , Yuichi Nakasone , Kyoko Akashi
- 申请人地址： JP Tokyo
- 专利权人： TOKYO UNIVERSITY OF SCIENCE EDUCATIONAL FOUNDATION ADMINISTRATIVE ORG.
- 当前专利权人： TOKYO UNIVERSITY OF SCIENCE EDUCATIONAL FOUNDATION ADMINISTRATIVE ORG.
- 当前专利权人地址： JP Tokyo
- 优先权： JP2008-230223 20080908; JP2008-230224 20080908
- 国际申请： PCT/JP2009/065641 WO 20090908
- 主分类号： C12N5/071
- IPC分类号： C12N5/071
摘要：
A spheroid composite includes: a substrate including a cell-adhesive porous base material and plural hydrophilic regions and hydrophobic regions that are disposed on the porous base material and formed by curing a photosensitive composition, wherein the photosensitive composition includes a branched polyalkylene glycol derivative having three or more polyalkylene glycol groups, each having a polymerizable substituent at a terminal thereof, and a tri- or higher-valent linking group that binds to the polyalkylene glycol groups; and spheroids formed in the hydrophobic regions on the substrate, the plural spheroids having a uniform size. A spheroid-containing hydrogel, which includes a hydrogel and two or more spheroids having a uniform size with a diameter of from 70 μm to 400 μm that are disposed in the hydrogel in such a manner that the two or more spheroids do not contact each other, can favorably maintain the function of the plural spheroids contained within the hydrogel.