发明申请
- 专利标题： GENETICALLY ENGINEERED CLOSTRIDIAL GENES, PROTEINS ENCODED BY THE ENGINEERED GENES, AND USES THEREOF
- 专利标题（中）： 遗传工程化遗传基因，工程基因编码的蛋白质及其用途
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申请号： US13252177申请日： 2011-10-03
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公开(公告)号： US20120021002A1公开(公告)日： 2012-01-26
- 发明人: Konstantin Ichtchenko , Philip A. Band
- 申请人： Konstantin Ichtchenko , Philip A. Band
- 申请人地址： US NY New York
- 专利权人： NEW YORK UNIVERSITY
- 当前专利权人： NEW YORK UNIVERSITY
- 当前专利权人地址： US NY New York
- 主分类号： A61K39/08
- IPC分类号： A61K39/08 ; A61P37/04 ; C07K14/33
摘要：
The present invention relates to an isolated Clostridial neurotoxin propeptide having a light chain region, a heavy chain region, where the light and heavy chain regions are linked by a disulfide bond, and an intermediate region connecting the light and heavy chain regions. An isolated nucleic acid molecule encoding a Clostridial neurotoxin propeptide is also disclosed. Also disclosed is an isolated, physiologically active Clostridial neurotoxin produced by cleaving a Clostridial neurotoxin propeptide, a vaccine or antidote thereof, and methods of immunizing against or treating for toxic effects of Clostridial neurotoxins. Methods of expressing recombinant physiologically active Clostridial neurotoxins are also disclosed. Also disclosed is a chimeric protein having a heavy chain region of a Clostridial neurotoxin and a protein with therapeutic functionality. A treatment method is also disclosed.
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