公开(公告)号：US20240096187A1

公开(公告)日：2024-03-21

申请号：US18091218

申请日：2022-12-29

申请人： New York University ,  New York University in Abu Dhabi Corporation

发明人： Prabodh Panindre ,  Shantanu ACHARYA ,  Kalidindi Nanda Kishore ,  Sunil Kumar

IPC分类号： G08B17/12 ,  G06V20/40 ,  G06V20/52

CPC分类号： G08B17/125 ,  G06V20/41 ,  G06V20/52

摘要： State-of-the-art object detection algorithms (e.g., EfficientDet, Faster-RCNN, and YOLO) and their variants are integrated into an end-to-end IoT cloud-based system deployment. The system can (1) receive real-time video streaming (RTSP/RTMP/SDP) from most CCTV systems and devices with cameras, (2) extract frames from the video streams, (3) feed the frames to multiple AI models simultaneously, and (4) compute a probability for the presence of fire and/or smoke. Based on custom risk thresholds, the outputs can be compiled programmatically into a video clip that is sent to a user automatically for real-time alerts.

公开(公告)号：US10540910B2

公开(公告)日：2020-01-21

申请号：US15614578

申请日：2017-06-05

申请人： NEW YORK UNIVERSITY ,  NEW YORK UNIVERSITY IN ABU DHABI CORPORATION

发明人： Mohamad Eid ,  Peter Loomer ,  Dianne Sefo ,  Georgios Korres ,  Georgios Karafotias

IPC分类号： G09B23/28 ,  G09B9/00

摘要： Existing haptic-based simulation systems struggle to replicate a realistic experience for dental and dental hygiene students and clinicians. A realistic haptic-based simulator to train periodontal procedures. Realism is accomplished through three distinguished features: (1) a custom grip to attach dental instruments to the haptic device, which enhances the grip experience since learners feel the tactile properties of the instruments (rather than the haptic device stylus), (2) two haptic devices are utilized to simulate haptic feedback with both the dental instrument (dominant hand) and the mirror instrument (non-dominant hand), and (3) a finger support mechanism using parallel manipulation is used for the intraoral fulcrum during probing. The Haptic dental simulator system comprises software and hardware subsystems. The software subsystem comprises of two Graphical User Interface (GUI) windows: the configuration window where an instructor defines periodontal exercises for learners to practice with and a simulation window where periodontal exercises are displayed for learners to interact with. The hardware subsystem includes two haptic devices with grips having the real instruments, and the finger support device.

公开(公告)号：US20240360475A1

公开(公告)日：2024-10-31

申请号：US18771850

申请日：2024-07-12

申请人： NEW YORK UNIVERSITY

发明人： Dounia ABBADI ,  Robert J. SCHNEIDER

IPC分类号： C12N15/86 ,  A61P21/00

CPC分类号： C12N15/86 ,  A61P21/00 ,  C12N2750/14143

摘要： The present application relates to an adeno-associated viral (AAV) vector, comprising a muscle cell-specific promoter and a nucleic acid molecule encoding an AU-rich mRNA binding factor 1 (AUF1) protein or a functional fragment thereof, where the nucleic acid molecule is heterologous to and operatively coupled to the muscle cell-specific promoter. Also disclosed are compositions comprising the AAV vector, as well as methods of promoting muscle regeneration in injured muscle, a method of treating degenerative skeletal muscle loss in a subject, methods of preventing traumatic muscle injury in a subject such as Duchenne Muscular Dystrophy, methods of treating traumatic muscle injury in a subject, and methods of treating muscle loss due to aging in a subject.

公开(公告)号：US12118388B2

公开(公告)日：2024-10-15

申请号：US17618797

申请日：2020-06-05

申请人： NEW YORK UNIVERSITY IN ABU DHABI CORPORATION

发明人： Benoit Marchand

IPC分类号： G06F9/50

CPC分类号： G06F9/50

摘要： An exemplary system, method and computer-accessible medium for assigning a plurality of tasks to a plurality of computing nodes can include, for example, receiving first information related to the computing nodes, where the first information can include a number of cores in each of the computing nodes, generating second information by separating the number of cores in each of the computing nodes, and assigning the tasks to the computing nodes based on the second information. The first information can further include (i) a distance of a network connection between each of the computer nodes, and (ii) a bandwidth of the network connection. The second information can be generated based on the tasks. The second information can be generated based on a number of dimensions of the tasks. The tasks can be assigned based on a minimization of a number of communications between the nodes.

公开(公告)号：US12116412B2

公开(公告)日：2024-10-15

申请号：US16489769

申请日：2018-03-05

申请人： NEW YORK UNIVERSITY

发明人： Daniel Meruelo ,  Alicia Hurtado Martinez ,  Christine Pampeno ,  Iris Scherwitzl

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C12N15/86

CPC分类号： C07K16/2818 ,  A61P35/00 ,  C07K14/705 ,  C12N15/86 ,  A61K39/00 ,  A61K2039/505 ,  C12N2770/36133 ,  C12N2770/36134 ,  C12N2770/36143 ,  C12N2770/36171

摘要： Provided are polynucleotides and viral vectors, e.g., alphavirus or Sindbis viral vectors, encoding multiple, e.g., two or more, epitopes of at least one tumor associated antigen, in which each epitope is separated by a processing or enzyme cleavage site. The encoded epitopes may be the same or different. Also provided are polynucleotides and viral vectors, particularly, alphavirus or Sindbis viral vectors, encoding an immune checkpoint protein, or a ligand binding portion thereof. The immune checkpoint protein or ligand binding portion thereof may be fused to immunoglobulin domains, e.g., an Ig hinge domain and an Ig heavy chain constant domain. Methods of treating subjects having a cancer or tumor, e.g., a TAA-expressing tumor, with the described viral vectors are provided. Treatment of subjects with the vectors, the checkpoint inhibitor molecules and/or other immunomodulatory components, generate an anti-cancer or anti-tumor immune response resulting in increased survivability of tumored subjects and epitope spreading.

公开(公告)号：US20240327542A1

公开(公告)日：2024-10-03

申请号：US18585676

申请日：2024-02-23

申请人： New York University

发明人： Shohei KOIDE ,  Benjamin NEEL ,  Carmine FEDELE ,  Kai Wen TENG ,  Akiko KOIDE ,  Takamitsu HATTORI ,  Lorenzo MASO

IPC分类号： C07K16/44 ,  A61K47/68 ,  C07K16/28

CPC分类号： C07K16/44 ,  A61K47/6849 ,  C07K16/2833 ,  C07K2317/56 ,  C07K2317/626

摘要： Provided are compositions and methods that include binding partners that bind with specificity to target sites on proteins or peptides that comprise a covalently attached molecule. The binding partners are provided as antibodies and antibody derivatives that specifically bind to proteins and peptides that have been covalently modified by attachment of a molecule, such as a drug. The binding partners can bind with specificity to covalently modified peptides when presented in the context of a major histocompatibility complex (MHC). Uses of the compositions and methods for prophylaxis or therapy of disorders are also provided.

公开(公告)号：US12103946B2

公开(公告)日：2024-10-01

申请号：US17284227

申请日：2019-10-08

申请人： New York University

发明人： Dan R. Littman ,  Jun R. Huh ,  Michael Fischbach

IPC分类号： A61K31/575 ,  A61P37/00 ,  C07J9/00 ,  C12N5/0783

CPC分类号： C07J9/005 ,  A61P37/00 ,  C12N5/0637 ,  A61K31/575 ,  C12N2501/15 ,  C12N2501/2302 ,  C12N2501/999

摘要： Steroid compounds are disclosed that have a formula represented by the following: (I) and wherein R1, R2, R3a, R3b, R4a, R4b, R5, R6a, R6b, R7, R8, and n are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for promoting differentiation of T regulatory (Treg) lymphocytes, and for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, and graft-versus-host disease.

公开(公告)号：US20240307444A1

公开(公告)日：2024-09-19

申请号：US18576076

申请日：2022-06-30

申请人： New York Genome Center, Inc. ,  New York University

发明人： Neville E. Sanjana ,  Mateusz Legut

IPC分类号： A61K35/17 ,  A61K39/00 ,  A61P35/02 ,  C07K14/705 ,  C07K14/725 ,  C12N5/0783 ,  C12N15/86 ,  G01N33/50

CPC分类号： A61K35/17 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/464412 ,  A61K39/464417 ,  A61K39/464468 ,  A61P35/02 ,  C07K14/7051 ,  C07K14/70578 ,  C12N5/0636 ,  C12N15/86 ,  G01N33/505 ,  A61K2239/48 ,  A61K2239/54 ,  C12N2510/00 ,  C12N2740/15043 ,  G01N2500/10

摘要： Provided herein are nucleic acids, expression cassettes, modified lymphocytes and compositions comprising the same which include a sequence encoding a gene of Table 1. In some embodiments, the gene is LTBR. In certain embodiments, the cell is a T cell. In certain embodiments, the cell further comprises a CAR or engineered TCR. Methods of treatment using the provided compositions are also described.

公开(公告)号：US12084500B2

公开(公告)日：2024-09-10

申请号：US17424474

申请日：2020-01-23

申请人： New York University ,  PureTech LYT, Inc.

发明人： Shohei Koide ,  George Miller ,  Akiko Koide ,  Tatyana Panchenko ,  Takamitsu Hattori ,  Aleksandra Filipovic ,  Eric Elenko ,  Joseph Bolen

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K39/00

CPC分类号： C07K16/2809 ,  A61P35/00 ,  C07K16/2818 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/92

摘要： Disclosed herein are antibodies specific to a delta-1 chain of a γδ T cell receptor and methods of using such for modulating γδ T cell bioactivity. Such anti-Delta 1 antibodies may also be used to treat diseases associated with γδ T cell activation, such as solid tumors, or for detecting presence of γδ1 T cells.

公开(公告)号：US20240294882A1

公开(公告)日：2024-09-05

申请号：US18593452

申请日：2024-03-01

申请人： NEW YORK UNIVERSITY

发明人： Benjamin tenOever

IPC分类号： C12N7/00 ,  A61K39/00 ,  A61K39/145 ,  C07K14/005 ,  C12N9/12 ,  C12N15/113

CPC分类号： C12N7/00 ,  A61K39/145 ,  C07K14/005 ,  C12N9/127 ,  C12N15/113 ,  C12Y207/07048 ,  A61K2039/5254 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16151

摘要： The present application provides an RNA-based system for generating a virus of the Orthomyxoviridae family, and methods of producing viruses of the Orthomyxoviridae family using such system.