Invention Application
- Patent Title: INDOLES, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR
- Patent Title (中): 吲哚，衍生物及其类似物及其用途
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Application No.: US13190150Application Date: 2011-07-25
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Publication No.: US20120022121A1Publication Date: 2012-01-26
- Inventor: James T. DALTON , Duane D. MILLER , Sunjoo AHN , Charles DUKE , Dong Jin HWANG , Jun YANG
- Applicant: James T. DALTON , Duane D. MILLER , Sunjoo AHN , Charles DUKE , Dong Jin HWANG , Jun YANG
- Main IPC: A61K31/404
- IPC: A61K31/404 ; C07D209/12 ; C07D277/64 ; C07D263/57 ; A61P35/04 ; A61K31/4184 ; A61K31/423 ; A61K31/428 ; A61P35/00 ; C07D403/10 ; C07D235/22
Abstract:
Indole derivatives and analogous compounds and pharmaceutical compositions comprising the same are provided. Also provided are methods of using these compounds to inhibit tubulin polymerization in a cell associated with a proliferative disease or to treat cancer, metastatic cancer, resistant cancer or multidrug resistant cancer, including inter-alia: prostate cancer, breast cancer, melanoma, colon cancer and bladder cancer.
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