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    CHROMENE COMPOUND
    4.
    发明申请
    CHROMENE COMPOUND 审中-公开
    铬化合物

    公开(公告)号：US20120270071A1

    公开(公告)日：2012-10-25

    申请号：US13386153

    申请日：2010-07-21

    申请人： Toshiaki Takahashi ,  Junji Takenaka

    发明人： Toshiaki Takahashi ,  Junji Takenaka

    IPC分类号： C07D235/22 ,  C07D491/02 ,  G02B5/23 ,  C07D498/04

    CPC分类号： C07D491/107 ,  C07D235/02 ,  C07D241/38 ,  C07D243/10 ,  C07D263/52 ,  C07D265/34 ,  C07D498/10

    摘要： A chromene compound having a skeleton represented by the following formula (1) and exhibiting double peak characteristic: wherein Z is a group represented by any one of the following formulas: n is an integer of 1 to 3, when n is 2 or 3, Z′ s may be the same or different, with the proviso that when n is 1, Z cannot be —CH2—, and when n is 2 or 3, Z's cannot be —CH2— at the same time; R1 is an electron absorbing group having a Hammett constant σp of more than 0, with the proviso that when there are a plurality of R1's, R1's may be the same or different; and X and Y are each independently an oxygen atom or ═NR2, with the proviso that X and Y cannot be oxygen atoms at the same time.

    摘要翻译： 具有由下式（1）表示的骨架并显示出双峰特性的色烯化合物：其中Z是由下列任何一个表示的基团：n是1至3的整数，当n是2或3时， Z可以相同或不同，条件是当n为1时，Z不能为-CH2-，当n为2或3时，Z不能同时为-CH2-; R1是具有大于0的哈米特常数p的电子吸收基团，条件是当存在多个R 1时，R 1可以相同或不同; X和Y各自独立地为氧原子或= NR2，条件是X和Y不能同时为氧原子。

    Substituted imidazolidines, process for their preparation, and their use as a medicament or diagnostic
    8.
    发明申请
    Substituted imidazolidines, process for their preparation, and their use as a medicament or diagnostic 审中-公开
    取代的咪唑烷，其制备方法及其作为药物或诊断用途

    公开(公告)号：US20030187045A1

    公开(公告)日：2003-10-02

    申请号：US10323799

    申请日：2002-12-20

    发明人： Uwe Heinelt ,  Hans-Jochen Lang ,  Armin Hofmeister ,  Klaus Wirth

    IPC分类号： A61K031/4184 ,  A61K031/4172 ,  C07D233/91 ,  C07D235/22 ,  C07D235/24

    CPC分类号： C07D235/02 ,  C07D233/50 ,  C07D235/30

    摘要： The invention relates to novel compounds of the type of the imidazolidines of the formula I 1 in which R1 to R7 are as defined herein. In one embodiment, these compounds are used for the treatment of the central nervous system, of lipid metabolism, of infection by ectoparasites, of disorders of gall function and for improving the respiratory drive such as for treating respiratory distress. In another embodiment, the compounds increase the muscle tone of the upper respiratory tract, thus suppressing snoring.

    摘要翻译： 本发明涉及式I的咪唑烷类型的新化合物，其中R 1至R 7如本文所定义。 在一个实施方案中，这些化合物用于治疗中枢神经系统，脂质代谢，外寄生虫感染，胆汁功能障碍和改善呼吸驱动，例如用于治疗呼吸窘迫。 在另一个实施方案中，化合物增加上呼吸道的肌肉紧张度，从而抑制打鼾。