发明申请
US20120028903A1 MODULATION OF THE ACTIVITY AND DIFFERENTIATION OF CELLS EXPRESSING THE OSTEOCLAST-ASSOCIATED RECEPTOR
失效
对表达OSTEOCLAST相关受体的细胞的活性和分化的调节
- 专利标题： MODULATION OF THE ACTIVITY AND DIFFERENTIATION OF CELLS EXPRESSING THE OSTEOCLAST-ASSOCIATED RECEPTOR
- 专利标题（中）： 对表达OSTEOCLAST相关受体的细胞的活性和分化的调节
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申请号： US13122637申请日： 2009-10-06
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公开(公告)号： US20120028903A1公开(公告)日： 2012-02-02
- 发明人: John Trowsdale , Alexander Barrow , Richard Farndale
- 申请人： John Trowsdale , Alexander Barrow , Richard Farndale
- 申请人地址： GB Cambridge
- 专利权人： Cambridge Enterprise Limited
- 当前专利权人： Cambridge Enterprise Limited
- 当前专利权人地址： GB Cambridge
- 优先权： GB0818273.5 20081006
- 国际申请： PCT/GB09/02382 WO 20091006
- 主分类号： A61K38/39
- IPC分类号： A61K38/39 ; C12Q1/02 ; C12N5/07 ; A61P35/02 ; A61P19/00 ; A61P35/00 ; A61P19/02 ; C07K14/78 ; C12Q1/42
摘要：
This invention relates to the finding that collagen peptides bind to the osteoclast-associated receptor (OSCAR) and stimulate the activation and/or differentiation of OSCAR expressing cells, such as osteoclasts and osteoclast precursor cells. Collagen peptides are described which may be useful in the modulation of the differentiation and/or activation of OSCAR expressing cells, for example in the treatment of bone defects and disorders characterized by altered differentiation and/or activation of OS-CAR expressing cells.
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