发明申请
- 专利标题： BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME
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申请号： US13269977申请日： 2011-10-10
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公开(公告)号： US20120028956A1公开(公告)日： 2012-02-02
- 发明人: P. Jeffrey Conn , Craig W. Lindsley , Charles David Weaver , Alice L. Rodriguez , Colleen M. Niswender , Carrie K. Jones , Richard Williams
- 申请人： P. Jeffrey Conn , Craig W. Lindsley , Charles David Weaver , Alice L. Rodriguez , Colleen M. Niswender , Carrie K. Jones , Richard Williams
- 主分类号： A61K31/4725
- IPC分类号： A61K31/4725 ; A61K31/496 ; A61K31/4375 ; A61K31/472 ; C07D413/06 ; C07D401/06 ; C07D471/04 ; C07D217/24 ; A61P25/24 ; C07D401/12 ; A61P25/28 ; A61P25/00 ; A61P25/18 ; A61P25/30 ; A61P25/08 ; A61P25/06 ; A61P3/10 ; A61P3/04 ; A61P3/00 ; A61P25/20 ; A61P25/22 ; A61K31/5377
摘要：
In one aspect, the invention relates to bicyclic mGluR5 positive allosteric modulators, for example 6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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