发明申请
- 专利标题: CARBOXYLIC ACID COMPOUND
- 专利标题(中): 羧酸化合物
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申请号: US13265781申请日: 2010-04-21
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公开(公告)号: US20120035196A1公开(公告)日: 2012-02-09
- 发明人: Kenji Negoro , Kei Ohnuki , Yasuhiro Yonetoku , Kazuyuki Kuramoto , Yasuharu Urano , Hideyuki Watanabe
- 申请人: Kenji Negoro , Kei Ohnuki , Yasuhiro Yonetoku , Kazuyuki Kuramoto , Yasuharu Urano , Hideyuki Watanabe
- 优先权: JP2009-103765 20090422
- 国际申请: PCT/JP2010/057034 WO 20100421
- 主分类号: A61K31/505
- IPC分类号: A61K31/505 ; C07C63/36 ; A61K31/216 ; A61K31/192 ; C07D239/34 ; C07D305/06 ; A61K31/337 ; C07D207/46 ; A61K31/4015 ; C07D309/10 ; A61K31/351 ; C07D317/18 ; A61K31/341 ; A61P3/10 ; C07C69/616
摘要:
[Problem]The present invention has an object to provide a compound having a GPR40 agonistic activity, which is useful as a pharmaceutical composition, an insulin secretion promoter, or an agent for preventing/treating diabetes.[Means for Solution]The present inventors have extensively studied a compound having a GPR40 agonistic activity, and as a result, they have found that the compound (I) of the present invention or a pharmaceutically acceptable salt thereof, in which a carboxylic acid is bonded to a bicyclic or tricyclic moiety through methylene, and further, a benzene ring substituted with a monocyclic 6-membered aromatic ring is bonded to a bicyclic or tricyclic moiety through —O-methylene or —NH-methylene, has an excellent GPR40 agonistic activity. They have also found that the compound has an excellent insulin secretion promoting action and strongly inhibits increase in the blood glucose after glucose loading, thereby completing the present invention.
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