利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

9 条记录 (耗时 0.054 秒)

    Cyclic tetrapeptide compound and use thereof
    4.
    发明申请
    Cyclic tetrapeptide compound and use thereof 审中-公开
    环状四肽化合物及其用途

    公开(公告)号：US20060229236A1

    公开(公告)日：2006-10-12

    申请号：US10500113

    申请日：2002-12-27

    申请人： Shigeki Satoh ,  Yasuharu Urano ,  Kazuhiko Osoda ,  Mitsuru Hosaka ,  Kozo Sawada ,  Takayuki Inoue ,  Hiroaki Mori ,  Shoji Takagaki ,  Takao Fujimura ,  Hideaki Matsuoka ,  Katsuhiko Yoshizawa

    发明人： Shigeki Satoh ,  Yasuharu Urano ,  Kazuhiko Osoda ,  Mitsuru Hosaka ,  Kozo Sawada ,  Takayuki Inoue ,  Hiroaki Mori ,  Shoji Takagaki ,  Takao Fujimura ,  Hideaki Matsuoka ,  Katsuhiko Yoshizawa

    IPC分类号： A61K38/12 ,  C07K5/12

    CPC分类号： C07K5/126 ,  A61K38/12

    摘要： A cyclic tetrapeptide compound of the formula (I): wherein R1 is hydrogen; R2 is lower alkyl, aryl, optionally substituted ar(lower)alkyl, heterocyclic(lower)alkyl, cyclo(lower)alkyl(lower)alkyl, lower alkylcarbamoyl(lower)alkyl or arylcarbamoyl(lower)alkyl; R3 and R4 are each independently hydrogen, lower alkyl, optionally substituted ar(lower)alkyl, optionally substituted heterocyclic(lower)alkyl or cyclo(lower)alkyl(lower)alkyl, or R3 and R4 are linked together to form lower alkylene or condensed ring, or one of R3 and R4 is linked to the adjacent nitrogen atom to form a ring; R5 is lower alkylene or lower alkenylene, Y is [wherein RY1 is hydrogen, halogen or optionally protected hydroxy, RY2 is hydrogen, halogen, lower alkyl or phenyl, and RY3 is hydrogen or lower alkyl]; R8 is hydrogen or lower alkyl; and n is an integer of 1 or 2, or a salt thereof.

    摘要翻译： 式（I）的环状四肽化合物：其中R 1是氢; R 2是低级烷基，芳基，任选取代的芳（低级）烷基，杂环（低级）烷基，环（低级）烷基（低级）烷基，低级烷基氨基甲酰基（低级）烷基或芳基氨基甲酰基 烷基; R 3和R 4各自独立地为氢，低级烷基，任选取代的芳（低级）烷基，任选取代的杂环（低级）烷基或环（低级）烷基（低级） ）烷基或R 3和R 4连接在一起形成低级亚烷基或稠环，或者R 3和R 3中的一个 > 4 与相邻的氮原子连接形成环; R 5是低级亚烷基或低级亚烯基，Y是[其中R Y1是氢，卤素或任选保护的羟基，R Y2是氢， 卤素，低级烷基或苯基，R 3 Y 3是氢或低级烷基]。 R 8是氢或低级烷基; n为1或2的整数，或其盐。