发明申请
US20120035199A9 SPIROHETEROCYCLIC COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS
审中-公开
螺旋体化合物及其作为治疗剂的用途
- 专利标题: SPIROHETEROCYCLIC COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS
- 专利标题(中): 螺旋体化合物及其作为治疗剂的用途
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申请号: US12855514申请日: 2010-08-12
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公开(公告)号: US20120035199A9公开(公告)日: 2012-02-09
- 发明人: Mikhail Chafeev , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Rajender Kamboj , Shifeng Liu , Mehran Seid Bagherzadeh , Jianyu Sun , Serguei Sviridov
- 申请人: Mikhail Chafeev , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Rajender Kamboj , Shifeng Liu , Mehran Seid Bagherzadeh , Jianyu Sun , Serguei Sviridov
- 申请人地址: CA Burnaby
- 专利权人: Xenon Pharmaceuticals Inc.
- 当前专利权人: Xenon Pharmaceuticals Inc.
- 当前专利权人地址: CA Burnaby
- 主分类号: A61K31/438
- IPC分类号: A61K31/438 ; C07D495/22 ; A61K31/407 ; A61P29/00 ; A61P25/04 ; A61P9/00 ; A61P11/00 ; A61P25/00 ; A61P25/06 ; C07D491/22 ; A61P25/24
摘要:
This invention is directed to spiroheterocyclic compounds of formula (I): wherein k, j, p, Q, R1, R3a, R3b, R3e, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, that are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of using the compounds are also disclosed.
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