发明申请
- 专利标题: MUTANT SMOOTHENED AND METHODS OF USING THE SAME
- 专利标题(中): MUTANT SMOOTHENED及其使用方法
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申请号: US13253317申请日: 2011-10-05
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公开(公告)号: US20120039893A1公开(公告)日: 2012-02-16
- 发明人: Frederic J. de Sauvage
- 申请人: Frederic J. de Sauvage
- 申请人地址: US CA South San Francisco
- 专利权人: Genentech, Inc.
- 当前专利权人: Genentech, Inc.
- 当前专利权人地址: US CA South San Francisco
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K14/435 ; C07K16/18 ; C12Q1/68 ; A61K31/496 ; G01N33/566 ; A61P35/00 ; A61K31/16 ; A61K31/4545 ; C07H21/04 ; C12Q1/02
摘要:
The emergence of mutations in tyrosine kinases following treatment of cancer patients with molecular-targeted therapy represents a major mechanism of acquired drug resistance. Here, we describe a mutation in the serpentine receptor, Smoothened (SMO), which results in resistance to a Hedgehog (Hh) pathway inhibitor in medulloblastoma. A single amino acid substitution in a conserved glutamic acid residue of SMO maintains Hh signaling, but results in the inability of the Hh pathway inhibitor, GDC-0449, to bind SMO and suppress the pathway. The invention provides screening methods to detect SMO mutations and methods to screen for drugs that specifically modulate mutant SMO exhibiting drug resistance.
公开/授权文献
- US08481680B2 Mutant smoothened and methods of using the same 公开/授权日:2013-07-09