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发明申请
US20120040385A1 COAGULOGEN RAW MATERIAL, PROCESS FOR PRODUCING THE SAME, AND METHOD AND APPARATUS FOR MEASURING PHYSIOLOGICALLY ACTIVE SUBSTANCE OF BIOLOGICAL ORIGIN USING THE SAME 有权
凝聚原料，其生产方法，以及使用该方法和装置测量生物原料的生理活性物质的方法和装置

  • 专利标题： COAGULOGEN RAW MATERIAL, PROCESS FOR PRODUCING THE SAME, AND METHOD AND APPARATUS FOR MEASURING PHYSIOLOGICALLY ACTIVE SUBSTANCE OF BIOLOGICAL ORIGIN USING THE SAME
  • 专利标题（中）： 凝聚原料，其生产方法，以及使用该方法和装置测量生物原料的生理活性物质的方法和装置
  • 申请号： US13202285
    申请日： 2010-02-19
  • 公开(公告)号： US20120040385A1
    公开(公告)日： 2012-02-16
  • 发明人: Katsumi Yabusaki
  • 申请人： Katsumi Yabusaki
  • 优先权： JP2009-037150 20090219
  • 国际申请： PCT/JP2010/052551 WO 20100219
  • 主分类号： C12Q1/56
  • IPC分类号： C12Q1/56 ;  C12P21/06 ;  C12M1/34 ;  C07K14/745
COAGULOGEN RAW MATERIAL, PROCESS FOR PRODUCING THE SAME, AND METHOD AND APPARATUS FOR MEASURING PHYSIOLOGICALLY ACTIVE SUBSTANCE OF BIOLOGICAL ORIGIN USING THE SAME
摘要：
Disclosed is a technique for obtaining a coagulogen raw material which can irreversibly inactivate the activity of a coagulase while retaining the function of coagulogen in an LAL reagent, a LAL reagent contaminated by an organism-derived biologically active substance or the like, and which can be used in a reagent. An LAL reagent is heated at a predetermined temperature for a predetermined period of time to deactivate only the activity of an enzyme contained in the LAL reagent irreversibly, wherein such an activity inherent in coagulogen that coagulogen can be hydrolyzed with the activated coagulase and converted to coagulin to induce gelatinization or an agglutination reaction is retained.
摘要（中）：

公开了一种获得凝固原料的技术，其能够在保留凝血酶原的作用的同时保持凝血酶原的功能而不可逆地灭活凝血酶原，LAL试剂，受生物体生物活性物质等污染的LAL试剂， 用于试剂。 将LAL试剂在预定温度下加热预定的时间，以不再可逆地仅使LAL试剂中包含的酶的活性不再激活，其中凝固酶原固有的这种活性可使凝固素可以用活化的凝固酶水解并转化为凝固素 以引起凝胶化或凝集反应。

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