发明申请
US20120058050A1 LOADED LATEX OPTICAL MOLECULAR IMAGING PROBES CONTAINING LIPOPHILIC LARGE STOKES SHIFT DYES
有权
装载LATEX光学分子成像探针，含有大量的食物转换染色体
- 专利标题： LOADED LATEX OPTICAL MOLECULAR IMAGING PROBES CONTAINING LIPOPHILIC LARGE STOKES SHIFT DYES
- 专利标题（中）： 装载LATEX光学分子成像探针，含有大量的食物转换染色体
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申请号： US13043057申请日： 2011-03-08
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公开(公告)号： US20120058050A1公开(公告)日： 2012-03-08
- 发明人: Tao Ji , Hans F. Schmitthenner , Yonghong Yang , John W. Harder , Jeffrey W. Leon , William J. Harrison , Brian J. Kelley , James R. Bennett , David A. Stegman , Ruizheng Wang
- 申请人： Tao Ji , Hans F. Schmitthenner , Yonghong Yang , John W. Harder , Jeffrey W. Leon , William J. Harrison , Brian J. Kelley , James R. Bennett , David A. Stegman , Ruizheng Wang
- 主分类号： G01N21/75
- IPC分类号： G01N21/75 ; A61K49/00 ; A61K47/32 ; B82Y15/00 ; B82Y5/00
摘要：
The present invention relates to a loaded particle comprising at least one fluorescent dye, and in particular, a fluorescent dye with a large Stokes shift. The invention further relates to a method for producing an loaded latex particle, loaded with a fluorescent dye having a large stokes shift. In addition, the present invention relates to latex particles loaded with fluorescent dyes that are organic solvent soluble and insoluble in water. In a preferred embodiment, when the dyes are loaded into the water soluble latex particle, an increase is observed in quantum yield of fluorescence as compared to the quantum yield of the dye in aqueous solvent.