发明申请
US20120064573A1 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES
有权
制备含有免费CYSTEINE残留物的蛋白质的方法
- 专利标题： METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES
- 专利标题（中）： 制备含有免费CYSTEINE残留物的蛋白质的方法
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申请号： US13088830申请日： 2011-04-18
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公开(公告)号： US20120064573A1公开(公告)日： 2012-03-15
- 发明人: George N. Cox , Daniel H. Doherty , Mary S. Rosendahl
- 申请人： George N. Cox , Daniel H. Doherty , Mary S. Rosendahl
- 主分类号： C12P21/00
- IPC分类号： C12P21/00
摘要：
The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form pegylated proteins.
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