发明申请
- 专利标题： RECOMBINANT FUSION PROTEIN AND POLYNUCLEOTIDE CONSTRUCT FOR IMMUNOTOXIN PRODUCTION
- 专利标题（中）： 重组融合蛋白和多核苷酸构建免疫霉素生产
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申请号： US13239847申请日： 2011-09-22
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公开(公告)号： US20120076780A1公开(公告)日： 2012-03-29
- 发明人: Itay Barnea , Itai Benhar , Rahamim Ben-Yosef , Akiva Vexler
- 申请人： Itay Barnea , Itai Benhar , Rahamim Ben-Yosef , Akiva Vexler
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C12N5/09 ; A61P35/00 ; C07K19/00
摘要：
The present invention relates to a polynucleotide construct encoding a fusion protein consisting of a domain which binds the immunoglobulin Fc region, genetically fused to a truncated form of Pseudomonas exotoxin A (PE). In particular, the invention discloses the fusion protein, ZZ-PE38, and further provides immunotoxins, formed from complexes of the fusion protein with antibodies for targeted cell killing.
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