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1.发明授权Recombinant fusion protein and polynucleotide construct for immunotoxin production 失效用于免疫毒素生产的重组融合蛋白和多核苷酸构建体公开(公告)号：US08329183B2
公开(公告)日：2012-12-11
申请号：US13233718
申请日：2011-09-15
申请人： Itai Benhar , Yariv Mazor
发明人： Itai Benhar , Yariv Mazor
IPC分类号： A61K39/104
CPC分类号： G01N33/5011 , A61K2039/505 , C07K14/21 , C07K2317/24 , C07K2319/30 , C07K2319/55 , C07K2319/705 , C12N15/62 , G01N33/6854
摘要： The present invention relates to a polynucleotide construct encoding a fusion protein consisting of a domain which binds the immunoglobulin Fc region, genetically fused to a truncated form of Pseudomonas exotoxin A (PE). In particular, the invention discloses the fusion protein, ZZ-PE38, and further provides immunotoxins, formed from complexes of the fusion protein with antibodies for targeted cell killing.
摘要翻译： 本发明涉及编码融合蛋白的多核苷酸构建体，该融合蛋白由与免疫球蛋白Fc区结合的结构域组成，遗传融合于假单胞菌外毒素A（PE）的截短形式。 特别地，本发明公开了融合蛋白ZZ-PE38，并进一步提供由融合蛋白与靶向细胞杀伤抗体形成的免疫毒素。
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2.发明申请HUMAN SYNTHETIC SINGLE-CHAIN ANTIBODIES DIRECTED AGAINST THE COMMON EPITOPE OF MUTANT P53 AND THEIR USES 失效针对P53突变体的共同抗原及其用途的人类合成单链抗体公开(公告)号：US20110262447A1
公开(公告)日：2011-10-27
申请号：US13180581
申请日：2011-07-12
申请人： Beka SOLOMON , Sara Orgad , Itai Benhar , Ronit Rosenfeld
发明人： Beka SOLOMON , Sara Orgad , Itai Benhar , Ronit Rosenfeld
IPC分类号： A61K39/395 , C12N15/86 , C12N7/01 , C07H21/04 , C12N15/85 , G01N33/574 , A61K31/7088 , C07K16/00 , A61K35/76 , C12N5/09
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/622 , C07K2317/92
摘要： Isolated polypeptides, isolated polynucleotides or expression vectors encoding same, viral display vehicles which can be specifically bind an exposed epitope shared by mutant, but not wild type, p53 protein are provided. Also provided are methods of inducing apoptosis and treating cancer as well as diagnosing a p53-related cancer using the isolated polypeptides uncovered by the present invention.
摘要翻译： 提供了分离的多肽，分离的多核苷酸或编码它们的表达载体，可以特异性结合由突变体而不是野生型p53蛋白共有的暴露表位的病毒显示载体。 还提供了诱导凋亡和治疗癌症以及使用本发明未覆盖的分离的多肽诊断p53相关癌症的方法。
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3.发明申请RECOMBINANT FUSION PROTEIN AND POLYNUCLEOTIDE CONSTRUCT FOR IMMUNOTOXIN PRODUCTION 失效重组融合蛋白和多核苷酸构建免疫霉素生产公开(公告)号：US20080292646A1
公开(公告)日：2008-11-27
申请号：US12117494
申请日：2008-05-08
申请人： Itai Benhar , Yariv Mazor
发明人： Itai Benhar , Yariv Mazor
IPC分类号： A61K39/395 , C12N15/11 , C12N15/00 , C12N5/06 , G01N33/574 , A61P31/00 , G01N33/53 , C12N1/20 , C07K16/18
CPC分类号： G01N33/5011 , A61K2039/505 , C07K14/21 , C07K2317/24 , C07K2319/30 , C07K2319/55 , C07K2319/705 , C12N15/62 , G01N33/6854
摘要： The present invention relates to a polynucleotide construct encoding a fusion protein consisting of a domain which binds the immunoglobulin Fc region, genetically fused to a truncated form of Pseudomonas exotoxin A (PE). In particular, the invention discloses the fusion protein, ZZ-PE38, and further provides immunotoxins, formed from complexes of the fusion protein with antibodies for targeted cell killing.
摘要翻译： 本发明涉及编码融合蛋白的多核苷酸构建体，该融合蛋白由与免疫球蛋白Fc区结合的结构域组成，遗传融合于假单胞菌外毒素A（PE）的截短形式。 特别地，本发明公开了融合蛋白ZZ-PE38，并进一步提供由融合蛋白与靶向细胞杀伤抗体形成的免疫毒素。
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公开(公告)号：US09624291B2
公开(公告)日：2017-04-18
申请号：US14005580
申请日：2012-03-15
申请人： Itai Benhar , Lilach Vaks
发明人： Itai Benhar , Lilach Vaks
CPC分类号： C07K16/468 , A61K2039/507 , C07K16/00 , C07K16/2878 , C07K16/32 , C07K2317/31 , C07K2317/522 , C07K2317/526 , C07K2317/55 , C07K2317/56 , C07K2317/60
摘要： An antibody is provided. The antibody comprises an Fc region and a Fab region, wherein: (i) the Fc region comprises two non-identical heavy chains, wherein at least one of the two non-identical heavy chains comprises an amino acid modification so as to form complementation between the two non-identical heavy chains thereby increasing the probability of forming heterodimers of the non-identical heavy chains and decreasing the probability of forming homodimers of identical heavy chains; and (ii) the Fab region comprises a first covalent link between a first heavy chain and a first light chain of the Fab region and a second covalent link between a second heavy chain and a second light chain of said Fab region, wherein a position of the first covalent link relative to the first heavy chain is different to a position of the second covalent link relative to the second heavy chain.
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公开(公告)号：US09321847B2
公开(公告)日：2016-04-26
申请号：US13823735
申请日：2011-08-22
申请人： Itai Benhar , Assaf Shapira , Meital Gal-Tanamy , Dana Greenfeld , Limor Nahary , Romy Zemel , Ran Tur-Kaspa
发明人： Itai Benhar , Assaf Shapira , Meital Gal-Tanamy , Dana Greenfeld , Limor Nahary , Romy Zemel , Ran Tur-Kaspa
IPC分类号： A61K39/00 , A61K39/29 , A61K39/385 , C07K16/46 , C07K14/21 , C07K14/415 , C12N9/14 , C12N9/50 , C12N15/62 , C07K14/195 , C07K14/32 , C07K14/37 , C07K14/705 , C07K16/10 , C07K16/18 , A61K38/00
CPC分类号： C07K16/46 , A61K38/00 , C07K14/195 , C07K14/21 , C07K14/32 , C07K14/37 , C07K14/415 , C07K14/705 , C07K16/1045 , C07K16/18 , C12N9/14 , C12N9/506 , C12N15/62 , Y02A50/465 , Y02A50/471
摘要： The present invention relates to activatable toxin complexes which include a cleavable inhibitory peptide. More specifically, the complexes comprise a cell targeting domain, a toxin catalytic domain, a specific protease cleavage site and an inhibitory peptide domain. The inhibitory peptide prevents the catalytic domain from exerting toxic effects until its release from the complex by the action of a protease, such a viral protease, at the protease cleavage site. Further provided are pharmaceutical compositions comprising the complexes and use thereof for treating infections and malignant disease.
摘要翻译： 本发明涉及包含可切割抑制肽的可活化毒素复合物。 更具体地，复合物包含细胞靶向结构域，毒素催化结构域，特异性蛋白酶切割位点和抑制性肽结构域。 抑制肽防止催化结构域在蛋白酶切割位点通过蛋白酶（例如病毒蛋白酶）的作用释放出毒性作用。 还提供了包含复合物的药物组合物及其用于治疗感染和恶性疾病的用途。
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公开(公告)号：US08563294B2
公开(公告)日：2013-10-22
申请号：US13322171
申请日：2010-05-26
申请人： Nathan Nelson , Iftach Yacoby , Ehud Gazit , Itai Benhar
发明人： Nathan Nelson , Iftach Yacoby , Ehud Gazit , Itai Benhar
CPC分类号： C12P3/00 , C07K14/80 , C12N9/0077
摘要： A cyanobacterial cell comprising a PSI complex which accepts electrons from at least one respiratory cytochrome is disclosed. Methods of generating same and use of same for the production of hydrogen gas are also disclosed.
摘要翻译： 公开了一种包含接受来自至少一种呼吸细胞色素的电子的PSI复合物的蓝细菌细胞。 还公开了生产氢气的方法及其使用方法。
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公开(公告)号：US20100203609A1
公开(公告)日：2010-08-12
申请号：US12670407
申请日：2008-07-23
申请人： Iftach Yacoby , Ehud Gazit , Nathan Nelson , Itai Benhar
发明人： Iftach Yacoby , Ehud Gazit , Nathan Nelson , Itai Benhar
CPC分类号： C12P3/00 , C12M21/02 , C12M21/18 , C12M31/10 , C12M47/10 , C12N9/0067 , C12N9/96 , C12N15/62 , C12Y112/98002
摘要： An isolated polypeptide comprising a hydrogen generating enzyme attached to a heterologous ferredoxin is disclosed, as well as polynucleotides encoding same, nucleic acid constructs capable of expressing same and cells expressing same. A method for generating hydrogen using the isolated polypeptide is also disclosed.
摘要翻译： 公开了包含与异源铁氧还蛋白连接的产氢酶的分离的多肽，以及编码其的多核苷酸，能够表达其的核酸构建体和表达相同的细胞。 还公开了使用分离的多肽产生氢的方法。
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公开(公告)号：US09181555B2
公开(公告)日：2015-11-10
申请号：US12670407
申请日：2008-07-23
申请人： Iftach Yacoby , Ehud Gazit , Nathan Nelson , Itai Benhar
发明人： Iftach Yacoby , Ehud Gazit , Nathan Nelson , Itai Benhar
CPC分类号： C12P3/00 , C12M21/02 , C12M21/18 , C12M31/10 , C12M47/10 , C12N9/0067 , C12N9/96 , C12N15/62 , C12Y112/98002
摘要： An isolated polypeptide comprising a hydrogen generating enzyme attached to a heterologous ferredoxin is disclosed, as well as polynucleotides encoding same, nucleic acid constructs capable of expressing same and cells expressing same. A method for generating hydrogen using the isolated polypeptide is also disclosed.
摘要翻译： 公开了包含与异源铁氧还蛋白连接的产氢酶的分离的多肽，以及编码其的多核苷酸，能够表达其的核酸构建体和表达相同的细胞。 还公开了使用分离的多肽产生氢的方法。
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9.发明申请RECOMBINANT FUSION PROTEIN AND POLYNUCLEOTIDE CONSTRUCT FOR IMMUNOTOXIN PRODUCTION 有权重组融合蛋白和多核苷酸构建免疫霉素生产公开(公告)号：US20120076780A1
公开(公告)日：2012-03-29
申请号：US13239847
申请日：2011-09-22
申请人： Itay Barnea , Itai Benhar , Rahamim Ben-Yosef , Akiva Vexler
发明人： Itay Barnea , Itai Benhar , Rahamim Ben-Yosef , Akiva Vexler
IPC分类号： A61K39/395 , C12N5/09 , A61P35/00 , C07K19/00
CPC分类号： C07K14/21 , A61K2039/505 , A61K2039/6037 , C07K16/3092 , C07K16/32 , C07K2317/24 , C07K2317/622 , C07K2317/92 , C07K2319/30 , C07K2319/55 , C07K2319/705 , C12N15/62 , G01N33/5011 , G01N33/6854
摘要： The present invention relates to a polynucleotide construct encoding a fusion protein consisting of a domain which binds the immunoglobulin Fc region, genetically fused to a truncated form of Pseudomonas exotoxin A (PE). In particular, the invention discloses the fusion protein, ZZ-PE38, and further provides immunotoxins, formed from complexes of the fusion protein with antibodies for targeted cell killing.
摘要翻译： 本发明涉及编码融合蛋白的多核苷酸构建体，该融合蛋白由与免疫球蛋白Fc区结合的结构域组成，遗传融合于假单胞菌外毒素A（PE）的截短形式。 具体地，本发明公开了融合蛋白ZZ-PE38，并进一步提供由融合蛋白与靶向细胞杀伤抗体形成的免疫毒素。
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10.发明授权Human synthetic single-chain antibodies directed against the common epitope of mutant P53 and their uses 失效针对突变P53的常见表位的人合成单链抗体及其用途公开(公告)号：US08039594B2
公开(公告)日：2011-10-18
申请号：US11887123
申请日：2006-03-23
申请人： Beka Solomon , Sara Orgad , Itai Benhar , Ronit Rosenfeld
发明人： Beka Solomon , Sara Orgad , Itai Benhar , Ronit Rosenfeld
IPC分类号： C12P21/08
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/622 , C07K2317/92
摘要： Isolated polypeptides, isolated polynucleotides or expression vectors encoding same, viral display vehicles which can be specifically bind an exposed epitope shared by mutant, but not wild type, p53 protein are provided. Also provided are methods of inducing apoptosis and treating cancer as well as diagnosing a p53-related cancer using the isolated polypeptides uncovered by the present invention.
摘要翻译： 提供了分离的多肽，分离的多核苷酸或编码它们的表达载体，可以特异性结合由突变体而不是野生型p53蛋白共有的暴露表位的病毒显示载体。 还提供了诱导凋亡和治疗癌症以及使用本发明未覆盖的分离的多肽诊断p53相关癌症的方法。
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