发明申请
- 专利标题: Methods for Increasing the Production of Ethanol from Microbial Fermentation
- 专利标题(中): 从微生物发酵中提高乙醇生产的方法
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申请号: US13314862申请日: 2011-12-08
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公开(公告)号: US20120083022A1公开(公告)日: 2012-04-05
- 发明人: James L. Gaddy , Dinesh K. Arora , Ching-Whan Ko , John Randall Phillips , Rahul Basu , Carl V. Wikstrom , Edgar C. Clausen
- 申请人: James L. Gaddy , Dinesh K. Arora , Ching-Whan Ko , John Randall Phillips , Rahul Basu , Carl V. Wikstrom , Edgar C. Clausen
- 申请人地址: US IL Lisle
- 专利权人: INEOS BIO LIMITED
- 当前专利权人: INEOS BIO LIMITED
- 当前专利权人地址: US IL Lisle
- 主分类号: C12P7/06
- IPC分类号: C12P7/06
摘要:
A stable continuous method for producing ethanol from the anaerobic bacterial fermentation of a gaseous substrate containing at least one reducing gas involves culturing in a fermentation bioreactor anaerobic, acetogenic bacteria in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor; and manipulating the bacteria in the bioreactor by reducing the redox potential, or increasing the NAD(P)H TO NAD(P) ratio, in the fermentation broth after the bacteria achieves a steady state and stable cell concentration in the bioreactor. The free acetic acid concentration in the bioreactor is maintained at less than 5 g/L free acid. This method allows ethanol to be produced in the fermentation broth in the bioreactor at a productivity of greater than 10 g/L per day. Both ethanol and acetate are produced in a ratio of ethanol to acetate ranging from 1:1 to 20:1.
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