A method and apparatus for avoiding in-device interference in a terminal equipped with multiple heterogeneous communication modules (e.g. Long Term Evolution (LTE), Wireless Local Area Network (WLAN), Bluetooth, and Global Positioning System (GPS) modules) are provided. The method includes one of detecting and predicting interference caused by the second communication module to communication of the first communication module, transmitting an interference occurrence information message to a base station for controlling to avoid the interference, and controlling to avoid the interference by executing one of a handover and discontinuous reception according to a control command included in an interference occurrence information response message transmitted by the base station. The terminal provides the cell with the interference-related information, the cell configures the Discontinuous Reception (DRX) based on the interference-related information, and the terminal can reduce in-device interference through the controlled DRX operation, resulting in improvement of communication reliability of the communication modules.