发明申请
US20120095046A1 Amido-Isothiazole Compounds and Their Use as Inhibitors of 11Beta-HSD1 for the Treatment of Metabolic Syndrome and Related Disorders
审中-公开
酰胺 - 异噻唑化合物及其作为11Beta-HSD1抑制剂用于治疗代谢综合征和相关疾病的用途
- 专利标题： Amido-Isothiazole Compounds and Their Use as Inhibitors of 11Beta-HSD1 for the Treatment of Metabolic Syndrome and Related Disorders
- 专利标题（中）： 酰胺 - 异噻唑化合物及其作为11Beta-HSD1抑制剂用于治疗代谢综合征和相关疾病的用途
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申请号： US13377611申请日： 2010-06-14
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公开(公告)号： US20120095046A1公开(公告)日： 2012-04-19
- 发明人: Scott Peter Webster , Jonathan Robert Seckl , Brian Robert Walker , Peter Ward , Thomas David Pallin , Hazel Joan Dyke , Trevor Robert Perrior
- 申请人： Scott Peter Webster , Jonathan Robert Seckl , Brian Robert Walker , Peter Ward , Thomas David Pallin , Hazel Joan Dyke , Trevor Robert Perrior
- 申请人地址： GB Edinburgh
- 专利权人： THE UNIVERSITY OF EDINBURGH
- 当前专利权人： THE UNIVERSITY OF EDINBURGH
- 当前专利权人地址： GB Edinburgh
- 国际申请： PCT/GB10/01155 WO 20100614
- 主分类号： A61K31/4709
- IPC分类号： A61K31/4709 ; C07D417/14 ; A61K31/427 ; C12N9/99 ; A61P43/00 ; A61P3/10 ; A61P3/08 ; A61P3/04 ; A61P3/06 ; A61P9/10 ; A61P9/00 ; A61P3/00 ; A61P1/16 ; A61P25/00 ; A61P25/18 ; A61P25/28 ; A61P25/16 ; A61P1/18 ; A61P27/06 ; A61P25/22 ; A61P25/24 ; A61P29/00 ; A61P19/10 ; A61P9/12 ; A61P27/02 ; A61P11/06 ; A61P11/00 ; A61P17/00 ; A61P1/00 ; A61P19/02 ; C07D413/06
摘要：
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-isothiazole compounds that, inter alia, inhibit 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11β-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.
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