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    Amido-thiophene compounds and their use
    1.
    发明授权
    Amido-thiophene compounds and their use 有权
    酰胺 - 噻吩化合物及其用途

    公开(公告)号：US08614209B2

    公开(公告)日：2013-12-24

    申请号：US13615497

    申请日：2012-09-13

    申请人： Scott Peter Webster ,  Jonathan Robert Seckl ,  Brian Robert Walker ,  Peter Ward ,  Thomas David Pallin ,  Hazel Joan Dyke ,  Trevor Robert Perrior

    发明人： Scott Peter Webster ,  Jonathan Robert Seckl ,  Brian Robert Walker ,  Peter Ward ,  Thomas David Pallin ,  Hazel Joan Dyke ,  Trevor Robert Perrior

    IPC分类号： A61K31/55 ,  C07D223/00

    CPC分类号： C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D487/04 ,  C07D487/08

    摘要： The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11β-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.

    摘要翻译： 本发明一般涉及治疗化合物领域。 更具体地说，本发明涉及特别是抑制1型11β-羟类固醇脱氢酶（11beta-HSD1）的某些酰氨基噻吩化合物。 本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内都用于抑制1型11β-羟类固醇脱氢酶的用途; 治疗通过抑制1型11β-羟类固醇脱氢酶而改善的病症; 治疗代谢综合征，其包括诸如2型糖尿病和肥胖症的疾病，以及包括胰岛素抵抗，高血压，脂质障碍和心血管疾病如缺血性（冠心病）心脏病的相关疾病; 治疗CNS疾病如轻度认知障碍和早期痴呆，包括阿尔茨海默氏病; 等等

    3,3-disubstituted-(8-aza-bicyclo[3.2.1]oct-8-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanones as inhibitors of 11 (β)-HSD1
    7.
    发明授权
    3,3-disubstituted-(8-aza-bicyclo[3.2.1]oct-8-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanones as inhibitors of 11 (β)-HSD1 有权
    3,3-二取代 - （8-氮杂 - 双环[3.2.1]辛-8-基） - [5-（1H-吡唑-4-基） - 噻吩-3-基] - 甲酮作为11 ＆bgr;） - HSD1

    公开(公告)号：US09365564B2

    公开(公告)日：2016-06-14

    申请号：US13642963

    申请日：2011-03-10

    申请人： Scott Peter Webster ,  Jonathan Robert Seckl ,  Brian Robert Walker ,  Peter Ward ,  Thomas David Pallin ,  Hazel Joan Dyke ,  Trevor Robert Perrior

    发明人： Scott Peter Webster ,  Jonathan Robert Seckl ,  Brian Robert Walker ,  Peter Ward ,  Thomas David Pallin ,  Hazel Joan Dyke ,  Trevor Robert Perrior

    IPC分类号： C07D451/06 ,  C07D451/02 ,  C07D409/14 ,  C07D451/04

    CPC分类号： C07D451/06 ,  C07D409/14 ,  C07D451/02 ,  C07D451/04

    摘要： The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 3,3-disubstituted-(8-aza-bicyclo[3.2.1]oct-8-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone, 3,3-disubstituted-(6-aza-bicyclo[3.1.1]hept-6-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone, and 4,4-disubstituted piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds of the following formula that, inter alia, inhibit 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11β-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.

    摘要翻译： 本发明一般涉及治疗化合物领域。 更具体地，本发明涉及某些3,3-二取代 - （8-氮杂 - 双环[3.2.1]辛-8-基） - [5-（1H-吡唑-4-基） - 噻吩-3-基 ] - 甲酮，3,3-二取代 - （6-氮杂 - 双环[3.1.1]庚-6-基） - [5-（1H-吡唑-4-基） - 噻吩-3-基] - 甲酮， 和4,4-二取代哌啶-1-基） - [5-（1H-吡唑-4-基） - 噻吩-3-基] - 甲酮化合物，其特别是抑制11-羟基类固醇脱氢酶 类型1（11＆bgr; -HSD1）。 本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，以抑制1型的1β-羟基类固醇脱氢酶; 治疗通过抑制11型β-羟基类固醇脱氢酶1改善的病症; 治疗代谢综合征，其包括诸如2型糖尿病和肥胖症的疾病，以及包括胰岛素抵抗，高血压，脂质障碍和心血管疾病如缺血性（冠心病）心脏病的相关疾病; 治疗CNS疾病如轻度认知障碍和早期痴呆，包括阿尔茨海默氏病; 等等

    HEIGHT-ADJUSTABLE WINDOW AIR CONDITIONER SUPPORT
    10.
    发明申请
    HEIGHT-ADJUSTABLE WINDOW AIR CONDITIONER SUPPORT 审中-公开
    高度可调式WINDOW AIR CONDITIONER支持

    公开(公告)号：US20080164390A1

    公开(公告)日：2008-07-10

    申请号：US11620695

    申请日：2007-01-07

    申请人： Brian Robert Walker

    发明人： Brian Robert Walker

    IPC分类号： F24F13/32

    CPC分类号： F24F13/32

    摘要： The present invention is directed to a height adjustable window air conditioner support that is rotatably adjusted to fit between a window air conditioner and a window ledge. In one embodiment, the support consists of two conjoined and threaded plastic cylindrical shafts, each of which, have a support platform on the opposing end.

    摘要翻译： 本发明涉及一种高度可调节的窗户空调支架，其被可旋转地调节以配合在窗户空调和窗台之间。 在一个实施例中，支撑件由两个连接和螺纹的塑料圆柱形轴组成，每个轴在其相对端具有支撑平台。