发明申请
- 专利标题: COMPOUND HAVING SPIRO-BONDED CYCLIC GROUP AND USE THEREOF
- 专利标题(中): 具有螺旋结合循环组的化合物及其用途
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申请号: US13378799申请日: 2010-06-15
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公开(公告)号: US20120101280A1公开(公告)日: 2012-04-26
- 发明人: Koji Yoshida , Hiroshi Ochiai , Kousuke Tani , Shiro Shibayama , Miki Kasano
- 申请人: Koji Yoshida , Hiroshi Ochiai , Kousuke Tani , Shiro Shibayama , Miki Kasano
- 申请人地址: JP Osaka
- 专利权人: ONO PHARMACEUTICAL CO., LTD.
- 当前专利权人: ONO PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: JP Osaka
- 优先权: JP2009-143458 20090616
- 国际申请: PCT/JP2010/060068 WO 20100615
- 主分类号: C07D471/10
- IPC分类号: C07D471/10
摘要:
The invention relates to a compound represented by formula (I): a salt thereof, an N-oxide thereof, or a solvate thereof (symbols in the formula are as described in the specification).The compound of the present invention exhibits very low risk of side effects and also has persistent and strong antagonistic activity against CXCR4, and is therefore useful as pharmaceuticals, for example, preventive and/or therapeutic agent for inflammatory and immune diseases, infections (for example, HIV infection), diseases associated with HIV infection (for example, acquired immunodeficiency syndrome (AIDS)), cancer, cancer metastasis, psychoneurotic diseases and cardiovascular diseases (for example, retinopathy), metabolic diseases, cancerous diseases, or an agent for regeneration therapy.
公开/授权文献
- US08476290B2 Compound having spiro-bonded cyclic group and use thereof 公开/授权日:2013-07-02
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