公开(公告)号：US08476290B2

公开(公告)日：2013-07-02

申请号：US13378799

申请日：2010-06-15

申请人： Koji Yoshida ,  Hiroshi Ochiai ,  Kousuke Tani ,  Shiro Shibayama ,  Miki Kasano

发明人： Koji Yoshida ,  Hiroshi Ochiai ,  Kousuke Tani ,  Shiro Shibayama ,  Miki Kasano

IPC分类号： A61K31/438 ,  C07D471/10

CPC分类号： C07D471/10

摘要： A compound represented by formula (I): a salt thereof, an N-oxide thereof, or a solvate thereof (symbols in the formula are as described in the specification). The compounds of the present invention exhibit very low risk of side effects and also have persistent and strong antagonistic activity against CXCR4, and are therefore useful as pharmaceuticals, for example, as a preventive and/or therapeutic agent for inflammatory and immune diseases, infections (for example, HIV infection), diseases associated with HIV infection (for example, acquired immunodeficiency syndrome (AIDS)), cancer, cancer metastasis, psychoneurotic diseases and cardiovascular diseases (for example, retinopathy), metabolic diseases, cancerous diseases, or as an agent for regeneration therapy.

摘要翻译： 由式（I）表示的化合物：其盐，其N-氧化物或其溶剂化物（式中的符号如说明书中所述）。 本发明的化合物显示出非常低的副作用风险，并且对CXCR4具有持久和强烈的拮抗活性，因此可用作药物，例如作为炎症和免疫疾病，感染的预防和/或治疗剂（ 例如艾滋病毒感染），与艾滋病毒感染有关的疾病（例如，获得性免疫缺陷综合征（AIDS）），癌症，癌症转移，精神神经病和心血管疾病（例如视网膜病变），代谢疾病，癌性疾病或作为 再生治疗剂。

公开(公告)号：US20120101280A1

公开(公告)日：2012-04-26

申请号：US13378799

申请日：2010-06-15

申请人： Koji Yoshida ,  Hiroshi Ochiai ,  Kousuke Tani ,  Shiro Shibayama ,  Miki Kasano

发明人： Koji Yoshida ,  Hiroshi Ochiai ,  Kousuke Tani ,  Shiro Shibayama ,  Miki Kasano

IPC分类号： C07D471/10

CPC分类号： C07D471/10

摘要： The invention relates to a compound represented by formula (I): a salt thereof, an N-oxide thereof, or a solvate thereof (symbols in the formula are as described in the specification).The compound of the present invention exhibits very low risk of side effects and also has persistent and strong antagonistic activity against CXCR4, and is therefore useful as pharmaceuticals, for example, preventive and/or therapeutic agent for inflammatory and immune diseases, infections (for example, HIV infection), diseases associated with HIV infection (for example, acquired immunodeficiency syndrome (AIDS)), cancer, cancer metastasis, psychoneurotic diseases and cardiovascular diseases (for example, retinopathy), metabolic diseases, cancerous diseases, or an agent for regeneration therapy.

摘要翻译： 本发明涉及由式（I）表示的化合物：其盐，其N-氧化物或其溶剂化物（式中的符号如说明书中所述）。 本发明的化合物显示出非常低的副作用风险，并且对CXCR4具有持久和强烈的拮抗活性，因此可用作药物，例如用于炎症和免疫疾病，感染的预防和/或治疗剂（例如 ，艾滋病毒感染），与艾滋病毒感染有关的疾病（例如，获得性免疫缺陷综合征（AIDS）），癌症，癌症转移，精神神经病和心血管疾病（例如视网膜病变），代谢疾病，癌性疾病或再生药剂 治疗。

公开(公告)号：US09129590B2

公开(公告)日：2015-09-08

申请号：US12528671

申请日：2008-02-29

申请人： Takuya Kawashima ,  Hiroyuki Ehara ,  Koji Yoshida

发明人： Takuya Kawashima ,  Hiroyuki Ehara ,  Koji Yoshida

IPC分类号： G10L19/00 ,  G10L19/005 ,  G10L19/12

CPC分类号： G10L19/005 ,  G10L19/12

摘要： Disclosed are an audio encoding device and an audio decoding device which reduce degradation of subjective quality of a decoding signal caused by power mismatch of a decoding signal which is generated by a concealing process upon disappearance of a frame. When a frame is lost, a past encoding parameter is used to obtain a concealed LPC of the current frame and a concealed sound source parameter. A normal CELP decoding is performed from the obtained concealed sound source parameter. Correction is performed by using a conceal parameter on the obtained concealed LPC and the concealed sound source signal. The power of the corrected concealed sound source signal is adjusted to match a reference sound source power. A filter gain of the synthesis filter is adjusted so as to adjust the power of a decoded sound signal to the power of a decoded sound signal during an error-free state. Moreover, a synthesis filter gain adjusting coefficient is calculated by using an estimated normalized residual power so that a filter gain of a synthesis filter formed by using a concealed LPC is a filter gain during an error-free state.

摘要翻译： 公开了一种音频编码装置和音频解码装置，其减少由于帧消失时由隐藏处理产生的解码信号的功率失配引起的解码信号的主观质量的劣化。 当帧丢失时，使用过去的编码参数来获得当前帧的隐藏的LPC和隐藏的声源参数。 从获得的隐藏声源参数执行正常的CELP解码。 通过对所获得的隐蔽LPC和隐藏的声源信号使用隐藏参数来执行校正。 校正的隐蔽声源信号的功率被调整以匹配参考声源功率。 调整合成滤波器的滤波器增益，以便在无错误状态期间将解码声音信号的功率调整为解码声音信号的功率。 此外，通过使用估计的归一化剩余功率来计算合成滤波器增益调整系数，使得通过使用隐藏的LPC形成的合成滤波器的滤波器增益在无错误状态期间是滤波器增益。

公开(公告)号：US09039604B2

公开(公告)日：2015-05-26

申请号：US13565645

申请日：2012-08-02

申请人： Koji Yoshida

发明人： Koji Yoshida

IPC分类号： A61B1/00 ,  A61B1/12 ,  A61B1/04 ,  A61M37/00 ,  A61M25/00 ,  A61M5/32 ,  A61M31/00 ,  A61B17/34 ,  A61B19/00

CPC分类号： A61B1/00006 ,  A61B1/126 ,  A61B17/3421 ,  A61B17/3474 ,  A61B90/70

摘要： An endoscope system including an endoscope insertion part to be inserted into a body cavity via a trocar stabbed in a body wall, the endoscope system comprising: a detecting device detecting whether a tip of the endoscope insertion part has been drawn inside the trocar; and a trocar cleaning device cleaning the inside of the trocar by supplying a predetermined fluid into the trocar when it is detected by the detecting device that the tip of the endoscope insertion part has been drawn inside the trocar.

摘要翻译： 一种内窥镜系统，包括：内窥镜插入部，经由穿过体壁的套针针插入到体腔内，所述内窥镜系统包括：检测装置，检测所述内窥镜插入部的尖端是否已经在所述套针针内被拉出; 以及套管针清洁装置，其通过在所述检测装置检测到所述内窥镜插入部的前端已经被拉出所述套针针时将规定的流体供给到所述套针针内而清洗所述套针针的内部。

公开(公告)号：US08812306B2

公开(公告)日：2014-08-19

申请号：US12307974

申请日：2007-07-11

申请人： Takuya Kawashima ,  Hiroyuki Ehara ,  Koji Yoshida

发明人： Takuya Kawashima ,  Hiroyuki Ehara ,  Koji Yoshida

IPC分类号： G10L21/00 ,  H04L1/00 ,  G10L19/005 ,  G10L25/90 ,  H04L12/56

CPC分类号： G10L19/005 ,  G10L25/90 ,  G10L2019/0011 ,  H04L47/10

摘要： An audio decoding device capable of suppressing an information amount for a lost flame compensation process and encoding efficiency is provided. A decoded sound source generator generates a lost frame's CELP decoded sound source signal. A pitch pulse information decoder CELP decodes a pitch pulse position information and a pitch pulse amplitude information. A pitch pulse waveform learner learns a pitch pulse learning waveform in a past frame in advance from the lost frame. A convolution adjuster amplitude-adjusts the pitch pulse learning waveform according to the pitch pulse amplitude information by considering a predetermined number of waveforms peripheral to a peak position of the lost frame's CELP decoded excitation signal, and convolutes a pitch pulse waveform into a time axis which has been amplitude-adjusted according to the pitch pulse position information. A sound source signal corrector adds or replaces the pitch pulse waveform convoluted into the time axis to the lost flame decoded sound source signal.

摘要翻译： 提供能够抑制失火补偿处理和编码效率的信息量的音频解码装置。 解码声源发生器产生丢失帧的CELP解码声源信号。 音调脉冲信息解码器CELP解码音调脉冲位置信息和音调脉冲幅度信息。 音调脉冲波形学习者从丢失的帧中预先学习过去帧中的音调脉冲学习波形。 卷积调整器通过考虑丢失帧的CELP解码的激励信号的峰值位置外围的预定数量的波形，根据音调脉冲幅度信息来振幅调整音调脉冲学习波形，并将音调脉冲波形卷曲成时间轴， 已经根据音调脉冲位置信息进行了幅度调整。 声源信号校正器将与时间轴卷积的音调脉冲波形相加或替换为失火解码声源信号。

公开(公告)号：US08809061B2

公开(公告)日：2014-08-19

申请号：US13412228

申请日：2012-03-05

申请人： Asuka Mukai ,  Koji Yoshida

发明人： Asuka Mukai ,  Koji Yoshida

IPC分类号： G01N31/00 ,  G01N1/28 ,  A61B8/00

CPC分类号： G01N1/2806 ,  A61B8/587 ,  G02B21/34 ,  Y10T436/10 ,  Y10T436/109163 ,  Y10T436/25

摘要： A living body phantom according to the present invention, which is used as a testing sample in a prepared slide in estimating the performance of a microscope objective lens with the image of the testing sample in the prepared slide acquired by an imaging means via the microscope objective lens and with optical characteristics obtained from the image of the testing sample, includes a non-gel-like solution at least including: a solvent which at least includes water, a refractive index adjustment agent, and a scattering body or which at least includes a refractive index adjustment agent and a scattering body; and a thickener.

摘要翻译： 根据本发明的活体体模，其用作准备的载玻片中的测试样品，以通过经成像装置通过显微镜物镜获得的准备的幻灯片中的测试样本的图像来估计显微镜物镜的性能 透镜，并且具有从测试样品的图像获得的光学特性，包括非凝胶状溶液，其至少包括：至少包括水的溶剂，折射率调节剂和散射体，或至少包括 折射率调节剂和散射体; 和增稠剂。

公开(公告)号：US08740779B2

公开(公告)日：2014-06-03

申请号：US13198583

申请日：2011-08-04

申请人： Koji Yoshida

发明人： Koji Yoshida

IPC分类号： A61B1/06 ,  A61B1/12

CPC分类号： A61B1/126 ,  A61B1/00091 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0653

摘要： In an imaging device for capturing an image by applying illuminating light emitted from a light source to a part to be observed through a light exit window and receiving light coming from the part to be observed when the illuminating light is applied, a light exit window cleaning unit discharges a liquid toward the light exit window to clean the light exit window in response to an instruction to start application of the illuminating light.

摘要翻译： 在用于通过从照明光施加从光源发射的照明光通过光出射窗口向被观察部分照射光并从待观察部分接收光的摄像装置中， 响应于开始施加照明光的指令，单元将液体朝向光出射窗口排出以清洁光出射窗。

公开(公告)号：US08670988B2

公开(公告)日：2014-03-11

申请号：US11658150

申请日：2005-06-29

申请人： Koji Yoshida

发明人： Koji Yoshida

IPC分类号： G10L19/00 ,  A61K38/16

CPC分类号： G10L19/012 ,  G10L25/78

摘要： There is provided an audio encoding device capable of causing a decoding side to freely select an audio decoding mode corresponding to a control method used for audio encoding and capable of generating data which can be decoded even when the decoding side does not correspond to the control method. The audio encoding device (100) outputs encoded data corresponding to an audio signal containing an audio component and encoded data corresponding to an audio signal containing no audio component. An audio encoding unit (102) encodes the input audio signal in a predetermined section unit and generates encoded data. An audio present/absent judgment unit (106) decides whether the input audio signal contains an audio component for each predetermined section. A bit embedding unit (104) performs synthesis of noise data only for those generated from the input audio signal of the voice absent section in the encoded data generated by the audio encoding unit (102), thereby acquiring encoded data corresponding to an audio signal containing an audio component and encoded data corresponding to an audio signal containing no audio component.

摘要翻译： 提供了一种音频编码装置，其能够使解码侧自由地选择与用于音频编码的控制方法相对应的音频解码模式，并且即使当解码侧不对应于控制方法时也能够生成即使解码的数据 。 音频编码装置（100）输出对应于包含音频分量的音频信号的编码数据和对应于不包含音频分量的音频信号的编码数据。 音频编码单元（102）以预定的部分单位对输入音频信号进行编码，并生成编码数据。 音频存在/不存在判断单元（106）判定输入音频信号是否包含每个预定部分的音频分量。 位嵌入单元（104）仅对由音频编码单元（102）生成的编码数据中的语音缺失部分的输入音频信号产生的噪声数据进行合成，从而获取对应于包含 音频分量和对应于不包含音频分量的音频信号的编码数据。

公开(公告)号：US08644526B2

公开(公告)日：2014-02-04

申请号：US12992791

申请日：2009-06-26

申请人： Hiroyuki Ehara ,  Takuya Kawashima ,  Koji Yoshida

发明人： Hiroyuki Ehara ,  Takuya Kawashima ,  Koji Yoshida

IPC分类号： H03G3/00

CPC分类号： G10L19/008

摘要： Fluctuation in decoded signal localization is suppressed to maintain the feel of stereo. A selection unit selects balance parameters when the balance parameters are input from a gain coefficient decoding unit, or selects balance parameters input from a gain coefficient calculation unit when there is no balance parameter input from the gain coefficient decoding unit, and outputs the selected balance parameters to a multiplication unit. The multiplication unit multiplies a gain coefficient input from the selection unit with a decoded monaural signal input from a monaural decoding unit to perform balance adjustment processing.

摘要翻译： 抑制解码信号定位的波动以保持立体感。 当从增益系数解码单元输入平衡参数时，选择单元选择平衡参数，或者当没有从增益系数解码单元输入的平衡参数时选择从增益系数计算单元输入的平衡参数，并输出所选择的平衡参数 到乘法单元。 乘法单元将从选择单元输入的增益系数与从单声道解码单元输入的解码单声道信号相乘，以进行平衡调整处理。

公开(公告)号：US08473288B2

公开(公告)日：2013-06-25

申请号：US12990697

申请日：2009-06-18

申请人： Toshiyuki Morii ,  Hiroyuki Ehara ,  Koji Yoshida

发明人： Toshiyuki Morii ,  Hiroyuki Ehara ,  Koji Yoshida

IPC分类号： G10L19/00

CPC分类号： G10L19/008 ,  G10L25/27

摘要： Disclosed are a quantizer, encoder, and the methods thereof, wherein the computational load is reduced when the values related to the transform coefficients of the principal component analysis transform are quantized when a principal component analysis transform is applied to code stereo. A quantizer includes a power correlation calculator which calculates the power of the left channel signal, the power of the right channel signal, and the correlation between the left channel signal and the right channel signal; an intermediate value calculator which calculates the intermediate value which is the difference between left channel signal the power and the right channel signal power; a codebook which holds a plurality of sets of the coefficients related to the transform coefficients of the principal component analysis transform and the code; and a quantizer which calculates the sum of the first multiplication result obtained by multiplying the coefficient by the correlation value and the second multiplication result obtained by multiplying the coefficient by the intermediate value as the cost function E, selects the coefficients where the cost function E becomes the maximum, and fetches the code related to the selected coefficients as the quantized code.

摘要翻译： 公开了一种量化器，编码器及其方法，其中当将主分量分析变换应用于代码立体声时，当与主成分分析变换的变换系数相关的值被量化时，计算负荷减小。 量化器包括功率相关计算器，其计算左声道信号的功率，右声道信号的功率，以及左声道信号和右声道信号之间的相关性; 中间值计算器，其计算作为左声道信号的功率和右声道信号功率之间的差的中间值; 码本，其保存与主成分分析变换和代码的变换系数相关的多个系数集合; 以及量化器，其计算通过将系数乘以相关值而获得的第一相乘结果与通过将系数乘以中间值而获得的第二乘法结果作为成本函数E的和，选择成本函数E变为 最大值，并且将与所选择的系数相关的代码作为量化代码获取。