发明申请
US20120108554A1 PROCESS FOR PREPARING HIGH PURITY 1alpha-HYDROXY VITAMIN D2
审中-公开
制备高纯度1α-羟基维生素D 2的方法
- 专利标题： PROCESS FOR PREPARING HIGH PURITY 1alpha-HYDROXY VITAMIN D2
- 专利标题（中）： 制备高纯度1α-羟基维生素D 2的方法
-
申请号： US12914739申请日： 2010-10-28
-
公开(公告)号： US20120108554A1公开(公告)日： 2012-05-03
- 发明人: Bang-I Liou , Ching-Peng Wei
- 申请人： Bang-I Liou , Ching-Peng Wei
- 申请人地址： TW Taoyuan
- 专利权人： FORMOSA LABORATORIES, INC.
- 当前专利权人： FORMOSA LABORATORIES, INC.
- 当前专利权人地址： TW Taoyuan
- 主分类号： A61K31/592
- IPC分类号： A61K31/592 ; A61P3/02 ; C07C401/00
摘要：
The present invention relates to a process for purifying Doxercalciferol, a synthetic vitamin D analog, also known as 1α-hydroxy vitamin D2, to the purity greater than 99.5% by crystallization from a mixed solvent of methanol and acetonitrile. Each of the individual impurities can be controlled no more than 0.1% which meets the individual unknown impurities specification requirement of International Conference on Harmonisation (ICH) guideline. The crystallization yield is more than 75% which is suitable for employed as a commercial process.
信息查询
