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17 条记录 (耗时 0.017 秒)

    PROCESS FOR PREPARING HIGH PURITY 1alpha-HYDROXY VITAMIN D2
    1.
    发明申请
    PROCESS FOR PREPARING HIGH PURITY 1alpha-HYDROXY VITAMIN D2 审中-公开
    制备高纯度1α-羟基维生素D 2的方法

    公开(公告)号：US20120108554A1

    公开(公告)日：2012-05-03

    申请号：US12914739

    申请日：2010-10-28

    申请人： Bang-I Liou ,  Ching-Peng Wei

    发明人： Bang-I Liou ,  Ching-Peng Wei

    IPC分类号： A61K31/592 ,  A61P3/02 ,  C07C401/00

    CPC分类号： C07C401/00 ,  C07B2200/13 ,  C07C2601/14 ,  C07C2602/24

    摘要： The present invention relates to a process for purifying Doxercalciferol, a synthetic vitamin D analog, also known as 1α-hydroxy vitamin D2, to the purity greater than 99.5% by crystallization from a mixed solvent of methanol and acetonitrile. Each of the individual impurities can be controlled no more than 0.1% which meets the individual unknown impurities specification requirement of International Conference on Harmonisation (ICH) guideline. The crystallization yield is more than 75% which is suitable for employed as a commercial process.

    摘要翻译： 本发明涉及一种通过从甲醇和乙腈的混合溶剂中结晶纯化多克多钙醇（一种合成维生素D类似物，也称为1α-羟基维生素D2），其纯度大于99.5％的方法。 每种杂质可以控制在不超过0.1％，符合国际会议协调（ICH）指南的各种未知杂质规格要求。 结晶产率大于75％，适合用作商业工艺。

    Preparation of Paricalcitol
    3.
    发明申请
    Preparation of Paricalcitol 审中-公开
    帕立骨糖醇的制备

    公开(公告)号：US20090275768A1

    公开(公告)日：2009-11-05

    申请号：US12112856

    申请日：2008-04-30

    申请人： Chze-Siong Ng ,  Ching-Peng Wei

    发明人： Chze-Siong Ng ,  Ching-Peng Wei

    IPC分类号： C07C401/00

    CPC分类号： C07C401/00

    摘要： This invention relates to a method for purifying Paricalcitol by reverse phase chromatography. This invention also relates to a purified Paricalcitol prepared by said method. This invention further relates to a method for purifying Paricalcitol by crystallization.

    摘要翻译： 本发明涉及通过反相色谱法纯化帕立骨化醇的方法。 本发明还涉及通过所述方法制备的精制帕立骨化醇。 本发明还涉及通过结晶纯化帕立骨化醇的方法。

    Method for preparing analogue of vitamin D
    5.
    发明申请
    Method for preparing analogue of vitamin D 审中-公开
    维生素D类似物的制备方法

    公开(公告)号：US20070088007A1

    公开(公告)日：2007-04-19

    申请号：US11477698

    申请日：2006-06-30

    申请人： Chze Ng ,  Ching-Peng Wei

    发明人： Chze Ng ,  Ching-Peng Wei

    IPC分类号： A61K31/59 ,  C07C401/00

    CPC分类号： C07C401/00

    摘要： A method for preparing analogues of C1,C24-dihydroxy-vitamin D is disclosed. Especially the method for preparing calcipotriol and tacalcitol from a starting material of Vitamin D2 is disclosed here. Calcipotriol (compound 1(a)) and tacalcitol (compound 1(b)) can be synthesized by the method of the present invention. Moreover, only nine steps are needed for the synthesis of calcipotriol using the method. Likewise, only ten steps are needed for the synthesis of tacalcitol by the present method. Hence, the present method, with less process steps and higher yields, represents an improvement over the conventional methods.

    摘要翻译： 公开了制备C1，C24-二羟基 - 维生素D类似物的方法。 特别地，本文公开了从维生素D 2的原料制备卡泊三醇和塔卡醇二醇的方法。 卡泊三醇（化合物1（a））和十五烷醇（化合物1（b））可以通过本发明的方法合成。 此外，使用该方法合成卡泊三醇需要9个步骤。 同样地，通过本方法合成塔卡醇二醇只需要十个步骤。 因此，本方法具有较少的工艺步骤和较高的产率，代表了相对于常规方法的改进。

    PROCESS FOR PREPARING TEMOZOLOMIDE
    6.
    发明申请
    PROCESS FOR PREPARING TEMOZOLOMIDE 审中-公开
    制备TEMOZOLOMIDE的方法

    公开(公告)号：US20120108811A1

    公开(公告)日：2012-05-03

    申请号：US12914311

    申请日：2010-10-28

    申请人： Mei-Jing Lee ,  Ching-Peng Wei

    发明人： Mei-Jing Lee ,  Ching-Peng Wei

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： This present invention provides an improved process for preparing Temozolomide (TMZ) stable at room temperature for at least 18 months. This present invention also relates to Temozolomide stable at room temperature for at least 18 months.

    摘要翻译： 本发明提供了在室温下稳定至少18个月的替莫唑胺（TMZ）的制备方法。 本发明还涉及在室温下稳定至少18个月的替莫唑胺。