A method and apparatus for defining transmission parameters of user equipment reference signals. The method includes estimating channel delay spreads of a plurality of user equipments scheduled for transmission at a particular transmission time period or sub-frame in an uplink for communication with a NodeB, and allocating transmission parameters to each scheduled user equipment of the plurality of user equipments in accordance to the delay spreads of the plurality of user equipments scheduled for transmission in the particular time period or sub-frame, wherein the parameters comprises a cyclic shift allocated to each m-th user equipment equal to the sum of a delay spread and a timing uncertainty of each of the previous m-1 user equipments.