发明申请
US20120114644A1 ANTAGONIST ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE PREVENTION AND TREATMENT OF NOTCH3-RELATED DISEASES
有权
ANTAGONIST ANTI-NOTCH3抗体及其在预防和治疗Notch3相关疾病中的应用
- 专利标题： ANTAGONIST ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE PREVENTION AND TREATMENT OF NOTCH3-RELATED DISEASES
- 专利标题（中）： ANTAGONIST ANTI-NOTCH3抗体及其在预防和治疗Notch3相关疾病中的应用
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申请号： US13353173申请日： 2012-01-18
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公开(公告)号： US20120114644A1公开(公告)日： 2012-05-10
- 发明人: Sek Chung Fung , Kang Li , Yucheng Li , Sanjaya Singh , Bin-Bing Stephen Zhou
- 申请人： Sek Chung Fung , Kang Li , Yucheng Li , Sanjaya Singh , Bin-Bing Stephen Zhou
- 申请人地址： US CA South San Francisco
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： US CA South San Francisco
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61P1/16 ; A61P3/10 ; C07K16/28 ; A61P35/00
摘要：
The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
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