发明申请
- 专利标题： Quinolinone PDE2 Inhibitors
- 专利标题（中）： 喹啉酮PDE2抑制剂
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申请号： US13384946申请日： 2010-07-19
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公开(公告)号： US20120115885A1公开(公告)日： 2012-05-10
- 发明人: Pablo De Leon , Melissa Egbertson , Ivory D. Hills , Adam Wayne Johnson , Michelle Machacek
- 申请人： Pablo De Leon , Melissa Egbertson , Ivory D. Hills , Adam Wayne Johnson , Michelle Machacek
- 国际申请： PCT/US10/42419 WO 20100719
- 主分类号： A61K31/4709
- IPC分类号： A61K31/4709 ; C07D409/04 ; C07D215/22 ; A61K31/4704 ; A61P25/18 ; C07D401/12 ; A61P25/22 ; A61P25/00 ; A61P25/16 ; C07D409/14 ; A61K31/506
摘要：
The present invention is directed to quinolinone compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
公开/授权文献
- US08680116B2 Quinolinone PDE2 inhibitors 公开/授权日：2014-03-25