A multi-secured RFID (Radio Frequency Identification) electronic seal includes a bolt, a bolt pedestal and a RFID system. The bolt has a male bolt portion with an electrical connecting point. The bolt pedestal has a female pedestal portion with several nodes to electrically connect with the electrical connecting point to provide plural selections of connecting and disconnecting. The RFID system includes a RFID chip and a transmission conductor embedded in the bolt, and an antenna installed on the bolt pedestal. When the bolt and the bolt pedestal is securely locked together, whether the RFID chip is electrically connects to the antenna depends on if the electrical connecting point connects a preset node, so that a RFID signal may be selectively transmitted by the RFID chip through the antenna.