发明申请
- 专利标题: ANTI-AXL ANTIBODY
- 专利标题(中): 抗轴抗体
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申请号: US13320317申请日: 2010-05-14
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公开(公告)号: US20120121587A1公开(公告)日: 2012-05-17
- 发明人: Atsuhiko Maeda , Hajime Miyamoto , Taichi Kuramochi , Atsushi Matsuo , Tomoyuki Igawa , Hirotake Shiraiwa , Hiroyuki Tsunoda , Tatsuhiko Tachibana
- 申请人: Atsuhiko Maeda , Hajime Miyamoto , Taichi Kuramochi , Atsushi Matsuo , Tomoyuki Igawa , Hirotake Shiraiwa , Hiroyuki Tsunoda , Tatsuhiko Tachibana
- 申请人地址: JP Tokyo
- 专利权人: CHUGAI SEIYAKU KABUSHIKI KAISHA
- 当前专利权人: CHUGAI SEIYAKU KABUSHIKI KAISHA
- 当前专利权人地址: JP Tokyo
- 优先权: JP2009-118725 20090515
- 国际申请: PCT/JP2010/058166 WO 20100514
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; A61P35/00 ; C07K16/28
摘要:
An objective of the present invention is to decrease the immunogenicity of mouse-derived anti-AXL antibodies in humans by humanizing them. The present invention provides antibodies that can bind to a specific region in Anexelekto (AXL) and humanized antibodies that are produced based on such antibodies. The anti-AXL antibodies of the present invention have high antitumor activity, and are useful as agents for decreasing the AXL expression level, antitumor agents, and diagnostic agents for cancer.
公开/授权文献
- US09340615B2 Anti-AXL antibody 公开/授权日:2016-05-17