Invention Application
- Patent Title: SPIRO-OXINDOLE MDM2 ANTAGONISTS
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Application No.: US13294315Application Date: 2011-11-11
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Publication No.: US20120122947A1Publication Date: 2012-05-17
- Inventor: Shaomeng Wang , Yujun Zhao , Wei Sun , Sanjeev Kumar , Lance Leopold , Laurent Debussche , Cedric Barriere , Jean-Christophe Carry , Kwame Amaning
- Applicant: Shaomeng Wang , Yujun Zhao , Wei Sun , Sanjeev Kumar , Lance Leopold , Laurent Debussche , Cedric Barriere , Jean-Christophe Carry , Kwame Amaning
- Applicant Address: US MI Ann Arbor FR Paris US PA Malvern
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN,SANOFI,ASCENTA THERAPEUTICS, INC.
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN,SANOFI,ASCENTA THERAPEUTICS, INC.
- Current Assignee Address: US MI Ann Arbor FR Paris US PA Malvern
- Main IPC: A61K31/407
- IPC: A61K31/407 ; A61P35/00 ; A61P35/02 ; C07D487/10
Abstract:
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
Public/Granted literature
- US08680132B2 Spiro-oxindole MDM2 antagonists Public/Granted day:2014-03-25
Information query
IPC分类:
