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272 条记录 (耗时 0.053 秒)

    Spiro-oxindole MDM2 antagonists
    6.
    发明授权
    Spiro-oxindole MDM2 antagonists 有权
    螺羟吲哚MDM2拮抗剂

    公开(公告)号：US08680132B2

    公开(公告)日：2014-03-25

    申请号：US13294315

    申请日：2011-11-11

    申请人： Shaomeng Wang ,  Wei Sun

    发明人： Shaomeng Wang ,  Wei Sun

    IPC分类号： A61K31/4015 ,  C07D209/34

    CPC分类号： A61N5/10 ,  A61K31/407 ,  A61K45/06 ,  C07D487/10 ,  A61K2300/00

    摘要： Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

    摘要翻译： 本文提供了药物化学领域中的化合物，组合物和方法。 本文提供的化合物和组合物涉及用作p53和MDM2之间相互作用的拮抗剂的螺 - 羟基吲哚，以及它们作为治疗癌症和其它疾病的治疗剂的用途。

    Tangerine peel extract and its preparation and application
    9.
    发明授权
    Tangerine peel extract and its preparation and application 有权
    橘皮提取物及其制备及应用

    公开(公告)号：US09167841B2

    公开(公告)日：2015-10-27

    申请号：US13355528

    申请日：2012-01-21

    申请人： Yiting Yang ,  Hujie Luo ,  Wei Sun ,  Haiyan Ou ,  Shuo Liu ,  Chungwah Ma

    发明人： Yiting Yang ,  Hujie Luo ,  Wei Sun ,  Haiyan Ou ,  Shuo Liu ,  Chungwah Ma

    IPC分类号： A61K36/752 ,  A23L1/30 ,  A23L1/212

    CPC分类号： A23L1/3002 ,  A23L19/07 ,  A23L33/105 ,  A61K2236/37

    摘要： This invention disclosed is a tangerine peel extract with the effect of weight gain. This extract uses tangerine peel as the raw ingredient and is obtained through extraction processes using supercritical CO2, water, or organic solvents. The resulting extraction component contains a large quantity of flavonoids and terpenoids, which can effectively regulate the function of the spleen and stomach leading to desired weight gain. This invention also declares the preparation methods of the above mentioned tangerine peel extraction, which is simple in technique and highly effective in extraction. This invention also further declares the application of the above mentioned tangerine peel extraction in preparing healthcare food with the function of gaining weight.

    摘要翻译： 本发明公开的是具有增重效果的橘皮提取物。 该提取物以橘皮为原料，采用超临界CO2，水或有机溶剂提取工艺得到。 所得提取组分含有大量类黄酮和萜类化合物，可有效调节脾胃功能，达到所需体重增加。 本发明还公开了上述橘皮提取的制备方法，其技术简单，萃取效率高。 本发明还进一步说明了上述橘皮提取在制备具有增重功能的保健食品中的应用。

    Auto-calibrated scanning-angle prism-type total internal reflection microscopy for nanometer-precision axial position determination and optional variable-illumination-depth pseudo total internal reflection microscopy
    10.
    发明授权
    Auto-calibrated scanning-angle prism-type total internal reflection microscopy for nanometer-precision axial position determination and optional variable-illumination-depth pseudo total internal reflection microscopy 有权
    自动校准扫描角度棱镜式全内反射显微镜，用于纳米精度轴向位置测定和可选可变照明深度伪全内反射显微镜

    公开(公告)号：US09012872B1

    公开(公告)日：2015-04-21

    申请号：US13006739

    申请日：2011-01-14

    申请人： Ning Fang ,  Wei Sun

    发明人： Ning Fang ,  Wei Sun

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6428 ,  G01N21/6458 ,  G01N21/648 ,  G02B21/16 ,  G02B21/26

    摘要： A method, apparatus, and system for improved VA-TIRFM microscopy. The method comprises automatically controlled calibration of one or more laser sources by precise control of presentation of each laser relative a sample for small incremental changes of incident angle over a range of critical TIR angles. The calibration then allows precise scanning of the sample for any of those calibrated angles for higher and more accurate resolution, and better reconstruction of the scans for super resolution reconstruction of the sample. Optionally the system can be controlled for incident angles of the excitation laser at sub-critical angles for pseudo TIRFM. Optionally both above-critical angle and sub critical angle measurements can be accomplished with the same system.

    摘要翻译： 一种用于改进VA-TIRFM显微镜的方法，装置和系统。 该方法包括通过精确控制每个激光器相对于样品的呈现的自动控制的校准，用于在临界TIR角度的范围内的小的增量变化的入射角度。 然后校准可以精确扫描样品，以获得更高和更准确的分辨率的任何校准角度，以及更好地重建扫描以进行超分辨率重建样品。 可选地，对于伪TIRFM，可以以亚临界角度对激发激光器的入射角度进行控制。 任选地，可以使用相同的系统来实现临界角和次临界角测量。