发明申请
US20120128640A1 HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS
审中-公开
异种干细胞的杂环化合物和扩增剂
- 专利标题： HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS
- 专利标题（中）： 异种干细胞的杂环化合物和扩增剂
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申请号： US13376280申请日： 2010-06-04
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公开(公告)号： US20120128640A1公开(公告)日： 2012-05-24
- 发明人: Taito Nishino , Shunsuke Iwamoto , Katsuaki Miyaji
- 申请人： Taito Nishino , Shunsuke Iwamoto , Katsuaki Miyaji
- 申请人地址： JP TOKYO
- 专利权人： NISSAN CHEMICAL INDUSTRIES LTD.
- 当前专利权人： NISSAN CHEMICAL INDUSTRIES LTD.
- 当前专利权人地址： JP TOKYO
- 优先权： JP2009-135495 20090604
- 国际申请： PCT/JP10/59552 WO 20100604
- 主分类号： A61K35/28
- IPC分类号： A61K35/28 ; C12N15/85 ; C12N5/077 ; C07D409/12 ; C07D409/14 ; C07D413/14 ; C07D333/32 ; A61K35/00 ; A61P7/00 ; A61P37/06 ; A61P37/04 ; A61P9/10 ; A61P25/00 ; A61P19/00 ; C12N5/02
摘要：
An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided.An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells containing a compound represented by the formula (I) (wherein X, Y, Z, Ar1, R1, R2, R3, R4, R5, R6 and R7 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells.