发明申请
- 专利标题： INHIBITORS OF PROTEIN KINASES
- 专利标题（中）： 蛋白激酶抑制剂
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申请号： US13360862申请日： 2012-01-30
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公开(公告)号： US20120129867A1公开(公告)日： 2012-05-24
- 发明人: Shawn M. Bauer , Zhaozhong J. Jia , Yonghong Song , Qing Xu , Mukund Mehrotra , Jack W. Rose , Wolin Huang , Chandrasekar Venkataramani , Anjali Pandey
- 申请人： Shawn M. Bauer , Zhaozhong J. Jia , Yonghong Song , Qing Xu , Mukund Mehrotra , Jack W. Rose , Wolin Huang , Chandrasekar Venkataramani , Anjali Pandey
- 申请人地址： US CA South San Francisco
- 专利权人： Portola Pharmaceuticals, Inc.
- 当前专利权人： Portola Pharmaceuticals, Inc.
- 当前专利权人地址： US CA South San Francisco
- 主分类号： A61K31/506
- IPC分类号： A61K31/506 ; C12N9/99 ; A61P9/00 ; A61P9/10 ; A61P37/08 ; A61P37/06 ; A61P29/00 ; A61P17/06 ; A61P13/12 ; A61P35/00 ; A61P7/06 ; C07D403/12 ; A61P11/06
摘要：
The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
公开/授权文献
- US08501944B2 Inhibitors of protein kinases 公开/授权日：2013-08-06