发明申请
- 专利标题: NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT
- 专利标题(中): 新颖的吲哚衍生物或其药学上可接受的盐作为蛋白激酶抑制剂用于增殖性疾病治疗,以及含有作为活性成分的药物组合物
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申请号: US13132772申请日: 2009-12-04
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公开(公告)号: US20120130069A1公开(公告)日: 2012-05-24
- 发明人: Tae Bo Sim , Jung Beom Son , Hwan Kim , Dong Sik Park , Hwan Geun Choi , Young Jin Ham , Jung Mi Hah , Kyung Ho Yoo , Chang Hyun Oh , So Ha Lee , Jae Du Ha , Sung Yun Cho , Byoung Mog Kwon , Dong Cho Han
- 申请人: Tae Bo Sim , Jung Beom Son , Hwan Kim , Dong Sik Park , Hwan Geun Choi , Young Jin Ham , Jung Mi Hah , Kyung Ho Yoo , Chang Hyun Oh , So Ha Lee , Jae Du Ha , Sung Yun Cho , Byoung Mog Kwon , Dong Cho Han
- 优先权: KR10-2008-0122999 20081205
- 国际申请: PCT/KR2009/007247 WO 20091204
- 主分类号: C07D413/14
- IPC分类号: C07D413/14 ; C07D409/12 ; C07D403/12 ; C07D405/12 ; A61P17/06 ; C07D401/12 ; C07D417/12 ; C07D417/14 ; A61P35/00 ; A61P35/02 ; C07D231/56 ; C07D413/12
摘要:
Disclosed are novel indazole derivatives represented by the following Chemical Formula 1 or pharmaceutically acceptable salts, hydrates or solvates thereof, and pharmaceutical compositions for the prevention or treatment of proliferative diseases, containing the same as an active ingredient. Having potent inhibitory effect against protein kinase, such as b-raf, KDR, Fms, Tie2, SAPK2a and Ret, inducing diseases caused by abnormal cell proliferation, the novel indazole derivatives can be used for the prevention or treatment of diseases caused by abnormal cell proliferation.