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1.发明授权Indazole derivatives or pharmaceutically acceptable salts thereof as protein kinase inhibitors for proliferative diseases treatment, and a pharmaceutical composition containing the same as an active ingredient 有权作为用于增殖性疾病治疗的蛋白激酶抑制剂的吲唑衍生物或其药学上可接受的盐，以及含有该活性成分的药物组合物公开(公告)号：US08754209B2
公开(公告)日：2014-06-17
申请号：US13132772
申请日：2009-12-04
Applicant: Tae Bo Sim , Jung Beom Son , Hwan Kim , Dong Sik Park , Hwan Geun Choi , Young Jin Ham , Jung Mi Hah , Kyung Ho Yoo , Chang Hyun Oh , So Ha Lee , Jae Du Ha , Sung Yun Cho , Byoung Mog Kwon , Dong Cho Han
Inventor： Tae Bo Sim , Jung Beom Son , Hwan Kim , Dong Sik Park , Hwan Geun Choi , Young Jin Ham , Jung Mi Hah , Kyung Ho Yoo , Chang Hyun Oh , So Ha Lee , Jae Du Ha , Sung Yun Cho , Byoung Mog Kwon , Dong Cho Han
IPC: C07D413/14 , C07D413/12 , C07D417/12 , C07D401/12 , C07D405/12 , C07D403/12 , C07D409/12 , C07D231/56
CPC classification number: C07D413/14 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
Abstract: Disclosed are novel indazole derivatives represented by the following Chemical Formula 1 or pharmaceutically acceptable salts, hydrates or solvates thereof, and pharmaceutical compositions for the prevention or treatment of proliferative diseases, containing the same as an active ingredient. Having potent inhibitory effect against protein kinase, such as b-raf, KDR, Fms, Tie2, SAPK2a and Ret, inducing diseases caused by abnormal cell proliferation, the novel indazole derivatives can be used for the prevention or treatment of diseases caused by abnormal cell proliferation.
Abstract translation: 公开了由以下化学式1表示的新型吲唑衍生物或其药学上可接受的盐，水合物或溶剂合物，以及用于预防或治疗增殖性疾病的药物组合物，其含有活性成分。 具有对蛋白激酶（如b-raf，KDR，Fms，Tie2，SAPK2a和Ret）的有效抑制作用，诱导由异常细胞增殖引起的疾病，该新型吲唑衍生物可用于预防或治疗由异常细胞引起的疾病 增殖。
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2.发明申请公开(公告)号：US20120271048A1
公开(公告)日：2012-10-25
申请号：US13504355
申请日：2010-10-20
Applicant: Tae Bo Sim , Young Jin Ham , Kyung Ho Yoo , Chang Hyun Oh , Jung Mi Hah , Hwan Geun Choi , Hwan Kim , Eun Jin Jun
Inventor： Tae Bo Sim , Young Jin Ham , Kyung Ho Yoo , Chang Hyun Oh , Jung Mi Hah , Hwan Geun Choi , Hwan Kim , Eun Jin Jun
IPC: C07D403/04 , C07D487/04 , C07D413/14
CPC classification number: C07D403/04 , A61K31/404 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04
Abstract: Disclosed are a 1,6-substituted indole compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of cancers caused by abnormal cell growth comprising the compound as an effective ingredient.Since the novel indole compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.
Abstract translation: 公开了具有蛋白激酶抑制活性的1,6-取代的吲哚化合物，药学上可接受的盐，以及用于预防和治疗由包含该化合物作为有效成分的异常细胞生长引起的癌症的药物组合物。 由于新型吲哚化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗由异常细胞生长引起的癌症的药剂。
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3.发明申请1,3,6-SUBSTITUTED INDOLE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE 有权具有蛋白激酶抑制活性的1,3,6-取代的吲哚衍生物公开(公告)号：US20110046370A1
公开(公告)日：2011-02-24
申请号：US12858114
申请日：2010-08-17
Applicant: Tae Bo Sim , Young Jin Ham , Kyung Ho Yoo , Chang Hyun Oh , Jung Mi Hah , Hwan Kim , Hwan Geun Choi , Jung-Hun Lee
Inventor： Tae Bo Sim , Young Jin Ham , Kyung Ho Yoo , Chang Hyun Oh , Jung Mi Hah , Hwan Kim , Hwan Geun Choi , Jung-Hun Lee
IPC: C07D401/14 , C07D401/04 , C07D413/14
CPC classification number: C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/14
Abstract: Disclosed are a 1,3,6-substituted indole compound having inhibitory activity for protein kinases, a pharmaceutically acceptable thereof, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth including the compound as an active ingredient.Since the novel indole compound exhibits superior inhibitory activity for various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.
Abstract translation: 公开了对蛋白激酶具有抑制活性的1,3,6-取代的吲哚化合物，其药学上可接受的物质，以及用于预防和治疗由异常细胞生长引起的疾病的药物组合物，包括该化合物作为活性成分。 由于新型吲哚化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗由异常细胞生长引起的癌症的药剂。
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公开(公告)号：US6166229A
公开(公告)日：2000-12-26
申请号：US556264
申请日：2000-04-24
Applicant: Henry Rapoport , Tae Bo Sim
Inventor： Henry Rapoport , Tae Bo Sim
IPC: C07D263/44 , C07C229/36
CPC classification number: C07D263/44
Abstract: Amino acids are derivatized for use in peptide synthesis by conversion to N-carboxyanhydrides that are N-protected by either a trityl or a phenylfluorenyl group.
Abstract translation: 氨基酸通过转化为被三苯甲基或苯基芴基N-保护的N-羧酸酐而被衍生化用于肽合成。
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公开(公告)号：US10112954B2
公开(公告)日：2018-10-30
申请号：US13575799
申请日：2011-01-28
Applicant: Seung Hyun Jung , Young Hee Jung , Wha Il Choi , Jung Beom Son , Eun Ju Jeon , In Ho Yang , Tae Hun Song , Mi Kyoung Lee , Myoung Sil Ko , Young Gil Ahn , Maeng Sup Kim , Young Jin Ham , Tae Bo Sim , Hwan Geun Choi , Jung Mi Hah , Dong-sik Park , Hwan Kim
Inventor： Seung Hyun Jung , Young Hee Jung , Wha Il Choi , Jung Beom Son , Eun Ju Jeon , In Ho Yang , Tae Hun Song , Mi Kyoung Lee , Myoung Sil Ko , Young Gil Ahn , Maeng Sup Kim , Young Jin Ham , Tae Bo Sim , Hwan Geun Choi , Jung Mi Hah , Dong-sik Park , Hwan Kim
IPC: C07D495/04 , A61K31/519 , A61P35/00 , A61P25/28 , A61P29/00 , A61P19/02
Abstract: The present invention relates to a novel bicyclic heteroaryl derivative, a pharmaceutically acceptable salt thereof, a hydrate thereof, and a solvate thereof having an improved inhibitory activity for protein kinases, and a pharmaceutical composition for preventing or treating an abnormal cell growth disorder comprising same as an active ingredient.
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Patent Agency Ranking
![THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES](/abs-image/US/2013/02/28/US20130053370A1/abs.jpg.150x150.jpg)
6.发明申请THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES 有权具有蛋白激酶抑制活性的THIENO [3,2-d]吡嗪衍生物公开(公告)号：US20130053370A1
公开(公告)日：2013-02-28
申请号：US13520656
申请日：2011-01-31
Applicant: Jung Beom Son , Seung Hyun Jung , Wha ll Choi , Young Hee Jung , Jae Yul Choi , Ji Yeon Song , Kyu Hang Lee , Jae Chul Lee , Eun Young Kim , Young Gil Ahn , Maeng Sup Kim , Hwan Geun Choi , Tae Bo Sim , Young Jin Ham , Dong-sik Park , Hwan Kim , Dong-Wook Kim
Inventor： Jung Beom Son , Seung Hyun Jung , Wha ll Choi , Young Hee Jung , Jae Yul Choi , Ji Yeon Song , Kyu Hang Lee , Jae Chul Lee , Eun Young Kim , Young Gil Ahn , Maeng Sup Kim , Hwan Geun Choi , Tae Bo Sim , Young Jin Ham , Dong-sik Park , Hwan Kim , Dong-Wook Kim
IPC: C07D495/04 , A61K31/5377 , A61P35/02 , A61P35/00 , A61P17/06 , A61K31/519 , A61K31/551
CPC classification number: C07D495/04
Abstract: The present invention relates to a thieno[3,2-d]pyrimidine derivative of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, which has an excellent inhibitory activity on protein kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating abnormal cell growth diseases.
Abstract translation: 本发明涉及对蛋白激酶具有优异抑制活性的式（I）的噻吩并[3,2-d]嘧啶衍生物或其药学上可接受的盐，水合物或溶剂合物，以及含有该噻吩并[3,2-d] 有效预防或治疗异常细胞生长疾病。
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![2,4,7-SUBSTITUTED THIENO[3,2-D]PYRIMIDINE COMPOUNDS AS PROTEIN KINASE INHIBITORS](/abs-image/US/2013/01/10/US20130012703A1/abs.jpg.150x150.jpg)
7.发明申请2,4,7-SUBSTITUTED THIENO[3,2-D]PYRIMIDINE COMPOUNDS AS PROTEIN KINASE INHIBITORS 有权作为蛋白激酶抑制剂的2,4,7-取代的三[3,2-D]吡啶化合物公开(公告)号：US20130012703A1
公开(公告)日：2013-01-10
申请号：US13510743
申请日：2010-10-22
Applicant: Tae Bo Sim , Jung Mi Hah , Hwan Geun Choi , Young Jin Ham , Jung Hun Lee , Dong Sik Park , Hwan Kim
Inventor： Tae Bo Sim , Jung Mi Hah , Hwan Geun Choi , Young Jin Ham , Jung Hun Lee , Dong Sik Park , Hwan Kim
IPC: C07D495/04
CPC classification number: C07D495/04
Abstract: Disclosed are a 2,4,7-substituted thieno[3,2-d]pyrimidine compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth comprising the compound as an effective ingredient.Since the novel 2,4,7-substituted thieno[3,2-d]pyrimidine compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating diseases caused by abnormal cell growth.
Abstract translation: 公开了具有蛋白激酶抑制活性的2,4,7-取代噻吩并[3,2-d]嘧啶化合物，药学上可接受的盐和用于预防和治疗由异常细胞生长引起的疾病的药物组合物，其包含化合物 作为有效成分。 由于新的2,4,7-取代噻吩并[3,2-d]嘧啶化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗由异常细胞引起的疾病 成长。
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8.发明授权1,3,6-substituted indole derivatives having inhibitory activity for protein kinase 有权具有蛋白激酶抑制活性的1,3,6-取代的吲哚衍生物公开(公告)号：US08329708B2
公开(公告)日：2012-12-11
申请号：US12858114
申请日：2010-08-17
Applicant: Tae Bo Sim , Young Jin Ham , Kyung Ho Yoo , Chang Hyun Oh , Jung Mi Hah , Hwan Kim , Hwan Geun Choi , Jung-Hun Lee
Inventor： Tae Bo Sim , Young Jin Ham , Kyung Ho Yoo , Chang Hyun Oh , Jung Mi Hah , Hwan Kim , Hwan Geun Choi , Jung-Hun Lee
IPC: A01N43/54 , C07D239/42 , C07D401/04
CPC classification number: C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/14
Abstract: Disclosed are a 1,3,6-substituted indole compound having inhibitory activity for protein kinases, a pharmaceutically acceptable thereof, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth including the compound as an active ingredient.Since the novel indole compound exhibits superior inhibitory activity for various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.
Abstract translation: 公开了对蛋白激酶具有抑制活性的1,3,6-取代的吲哚化合物，其药学上可接受的物质，以及用于预防和治疗由异常细胞生长引起的疾病的药物组合物，包括该化合物作为活性成分。 由于新型吲哚化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗由异常细胞生长引起的癌症的药剂。
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公开(公告)号：US20070149613A1
公开(公告)日：2007-06-28
申请号：US11603688
申请日：2006-11-21
Applicant: Cheol-Kyu Han , Jeong-Hyeok Yoon , Seung-Moak Kim , Nam-Doo Kim , Byung-Ha Chang , Jee-Young Lee , Tae-Bo Sim
Inventor： Cheol-Kyu Han , Jeong-Hyeok Yoon , Seung-Moak Kim , Nam-Doo Kim , Byung-Ha Chang , Jee-Young Lee , Tae-Bo Sim
IPC: A61K31/336
CPC classification number: C07D303/22 , C07D405/12 , C07D407/12
Abstract: The disclosure relates to a fumagillol compound which can be usefully used not only as an angiogenesis inhibiting agent showing a superior angiogenesis inhibitory effect with less toxicity, but also as a cancer metastasis inhibitor and a therapeutic agent against cancer and other various inflammatory diseases such as rheumatic disease, psoriasis, etc., and diabetic retinopathy related to angiogenesis, and also a method for preparing the same.
Abstract translation: 本公开涉及一种烟曲霉醇化合物，其不仅可以有效地用作显示出较低毒性的优异的血管发生抑制作用的血管生成抑制剂，而且可用作癌症转移抑制剂和抗癌剂等各种炎性疾病如风湿性的治疗剂 疾病，牛皮癣等，以及与血管发生有关的糖尿病性视网膜病变，以及其制备方法。
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公开(公告)号：US08765749B2
公开(公告)日：2014-07-01
申请号：US13504355
申请日：2010-10-20
Applicant: Tae Bo Sim , Young Jin Ham , Kyung Ho Yoo , Chang Hyun Oh , Jung Mi Hah , Hwan Geun Choi , Hwan Kim , Eun Jin Jun
Inventor： Tae Bo Sim , Young Jin Ham , Kyung Ho Yoo , Chang Hyun Oh , Jung Mi Hah , Hwan Geun Choi , Hwan Kim , Eun Jin Jun
IPC: C07D403/04 , A61K31/404 , C07D403/14 , C07D405/14
CPC classification number: C07D403/04 , A61K31/404 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04
Abstract: Disclosed are a 1,6-substituted indole compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of cancers caused by abnormal cell growth comprising the compound as an effective ingredient.Since the novel indole compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.
Abstract translation: 公开了具有蛋白激酶抑制活性的1,6-取代的吲哚化合物，药学上可接受的盐，以及用于预防和治疗由包含该化合物作为有效成分的异常细胞生长引起的癌症的药物组合物。 由于新型吲哚化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗由异常细胞生长引起的癌症的药剂。
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