发明申请
- 专利标题： CELL PENETRATING PEPTIDES AND ITS USE FUSED TO BIOMOLECULES WITH THERAPEUTIC ACTION
- 专利标题（中）： 细胞穿刺肽及其用于治疗生物分子的用途
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申请号： US12671335申请日： 2008-07-31
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公开(公告)号： US20120135021A1公开(公告)日： 2012-05-31
- 发明人: Isis del Carmen Torens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
- 申请人： Isis del Carmen Torens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
- 优先权： CU2007-0180 20070731
- 国际申请： PCT/CU2008/000006 WO 20080731
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; C07K19/00 ; A61P35/00 ; C07K7/08
摘要：
The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein Limulus antilipopolisacárido (LALF) and its analogous. This invention refers to compositions containing these peptides associated to biomolecules with therapeutics properties. This invention consist of compositions comprise the covalent fusion of biomolecules, between this human papillomavirus antigens (HPV) to these CPP for induce a potent immune cellular responses against HPV and HPV protein antigen-exhibiting cells including HPV-associated tumors. The referred compositions are applicable in the pharmaceutical industry as vaccine for therapeutic use in human.
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