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1.发明申请CELL PENETRATING PEPTIDES AND ITS USE FUSED TO BIOMOLECULES WITH THERAPEUTIC ACTION 有权细胞穿刺肽及其用于治疗生物分子的用途公开(公告)号：US20120135021A1
公开(公告)日：2012-05-31
申请号：US12671335
申请日：2008-07-31
申请人： Isis del Carmen Torens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
发明人： Isis del Carmen Torens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
CPC分类号： A61K39/12 , A61K2039/585 , A61K2039/6031 , C12N2710/20034
摘要： The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein Limulus antilipopolisacárido (LALF) and its analogous. This invention refers to compositions containing these peptides associated to biomolecules with therapeutics properties. This invention consist of compositions comprise the covalent fusion of biomolecules, between this human papillomavirus antigens (HPV) to these CPP for induce a potent immune cellular responses against HPV and HPV protein antigen-exhibiting cells including HPV-associated tumors. The referred compositions are applicable in the pharmaceutical industry as vaccine for therapeutic use in human.
摘要翻译： 本发明涉及使用新的细胞穿透肽（CPP），特别涉及蛋白鲎抗脂蛋白（LALF）的区域32-51及其类似物。 本发明涉及包含与具有治疗学性质的生物分子相关联的这些肽的组合物。 本发明由组合物组成，包括生物分子的共价融合，在该人乳头状瘤病毒抗原（HPV）与这些CPP之间，用于诱导对HPV和HPV蛋白抗原呈递细胞（包括HPV相关肿瘤）的有效免疫细胞应答。 所提及的组合物可用作制药工业中用于人类治疗用途的疫苗。
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2.发明授权Cell penetrating peptides and its use fused to biomolecules with therapeutic action 有权细胞穿透肽及其使用与具有治疗作用的生物分子融合公开(公告)号：US08673313B2
公开(公告)日：2014-03-18
申请号：US12671335
申请日：2008-07-31
申请人： Isis del Carmen Torrens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
发明人： Isis del Carmen Torrens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
CPC分类号： A61K39/12 , A61K2039/585 , A61K2039/6031 , C12N2710/20034
摘要： The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein Limulus antilipopolisacárido (LALF) and its analogous. This invention refers to compositions containing these peptides associated to biomolecules with therapeutics properties. This invention consist of compositions comprise the covalent fusion of biomolecules, between this human papillomavirus antigens (HPV) to these CPP for induce a potent immune cellular responses against HPV and HPV protein antigen-exhibiting cells including HPV-associated tumors. The referred compositions are applicable in the pharmaceutical industry as vaccine for therapeutic use in human.
摘要翻译： 本发明涉及使用新的细胞穿透肽（CPP），特别涉及蛋白鲎抗脂蛋白（LALF）的区域32-51及其类似物。 本发明涉及包含与具有治疗学性质的生物分子相关联的这些肽的组合物。 本发明由组合物组成，包括生物分子的共价融合，在该人乳头状瘤病毒抗原（HPV）与这些CPP之间，用于诱导对HPV和HPV蛋白抗原呈递细胞（包括HPV相关肿瘤）的有效免疫细胞应答。 所提及的组合物可用作制药工业中用于人类治疗用途的疫苗。
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公开(公告)号：US20090221508A1
公开(公告)日：2009-09-03
申请号：US12278990
申请日：2007-02-23
申请人： Maribel Guerra Vallespi , Isis del Carmen Torrrens Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Gerardo Enrique Guillen Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gomez
发明人： Maribel Guerra Vallespi , Isis del Carmen Torrrens Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Gerardo Enrique Guillen Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gomez
CPC分类号： C07K14/43509 , A61K38/00
摘要： The present invention is related to the development of peptides derived from the sequence HYRIKPTFRRLKWKKYKGKFW, showing aminoacids substitutions, these peptides unable to bind to the lipopolysaccharide and bearing anti-tumoral and immunomodulatory capacities. These peptides alone or in combination are useful to treat cancer, and also in synergy with conventional therapies.
摘要翻译： 本发明涉及来自序列HYRIKPTFRRLKWKKYKGKFW的肽的开发，显示出氨基酸取代，这些肽不能结合脂多糖并具有抗肿瘤和免疫调节能力。 单独或组合的这些肽可用于治疗癌症，并且与常规疗法协同作用。
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公开(公告)号：US08283324B2
公开(公告)日：2012-10-09
申请号：US12278990
申请日：2007-02-23
申请人： Maribel Guerra Vallespi , Isis del Carmen Torréns Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Gerardo Enrique Guillén Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gómez
发明人： Maribel Guerra Vallespi , Isis del Carmen Torréns Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Gerardo Enrique Guillén Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gómez
CPC分类号： C07K14/43509 , A61K38/00
摘要： The present invention is related to the development of peptides derived from the sequence HYRIKPTFRRLKWKYKGKFW (SEQ ID NO.: 13), showing amino acid substitutions, these peptides unable to bind to the lipopolysaccharides and bearing anti-tumoral and immunomodulatory capacities. These peptides alone or in combination are useful to treat cancer, and also in synergy with conventional therapies.
摘要翻译： 本发明涉及来自序列HYRIKPTFRRLKWKYKGKFW（SEQ ID NO：13）的肽的开发，显示氨基酸取代，这些肽不能结合脂多糖并具有抗肿瘤和免疫调节能力。 单独或组合的这些肽可用于治疗癌症，并且与常规疗法协同作用。
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公开(公告)号：US20090215730A1
公开(公告)日：2009-08-27
申请号：US11920031
申请日：2006-05-05
申请人： Rolando Eduardo Rodriguez Fernandez , Roberto Vera Alvarez , Ania De La Nuez Veulens , Yuliet Mazola Reyes , Silvio Ernesto Perea Rodriguez , Boris Ernesto Acevedo Castro , Alexis Musacchio Lasa , Raimundo Ubieta Gomez
发明人： Rolando Eduardo Rodriguez Fernandez , Roberto Vera Alvarez , Ania De La Nuez Veulens , Yuliet Mazola Reyes , Silvio Ernesto Perea Rodriguez , Boris Ernesto Acevedo Castro , Alexis Musacchio Lasa , Raimundo Ubieta Gomez
IPC分类号： A61K31/17 , A61K31/66 , A61K31/53 , A61K31/505 , A61K31/47 , A61K31/415 , A61K31/40 , A61K31/34 , A61K31/27 , A61K31/16 , A61K31/175 , A61K31/13 , C07D251/02 , C07D473/00 , C07D239/02 , C07D215/38 , C07D235/00 , C07D233/96 , C07D209/14 , C07D307/02 , C07C229/00 , C07F9/02 , C07C281/02 , C07C273/02 , C07C303/00 , C07C241/00
CPC分类号： C07C211/14 , C07C237/06 , C07C237/22 , C07C243/28 , C07C255/42 , C07C257/14 , C07C271/22 , C07C271/64 , C07C275/08 , C07C275/16 , C07C275/24 , C07C281/12 , C07C317/28 , C07C327/42 , C07C337/08 , C07D207/34 , C07D209/14 , C07D213/81 , C07D213/82 , C07D215/46 , C07D233/88 , C07D233/91 , C07D235/14 , C07D239/36 , C07D239/46 , C07D239/54 , C07D251/22 , C07D307/52 , C07D487/04 , C07F9/224
摘要： Chemical compounds derived by in silico molecular modelling, having a well defined structure suitable for the blocking of the phosphorylation event, through the specific interaction of the chemical with the Casein Kinase 2 enzyme substrate phosphorylation domain or it's neighbourhood. This invention comprises also the pharmaceutical compositions containing such compounds, and their use in the preparation of medicines or agents for the treatment of diseases or conditions related with neoplasic processes.
摘要翻译： 通过在硅分子模拟中得到的化学化合物通过化学物质与酪蛋白激酶2酶底物磷酸化结构域或其邻域的特异性相互作用具有适合于阻断磷酸化事件的良好定义的结构。 本发明还包含含有这些化合物的药物组合物及其在制备用于治疗与肿瘤过程相关的疾病或病症的药物或试剂中的用途。
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公开(公告)号：US08883724B2
公开(公告)日：2014-11-11
申请号：US12612455
申请日：2009-11-04
申请人： Mónica Bequet Romero , Boris Ernesto Acevedo Castro , Jorge Victor Gavilondo Cowley , Luis Enrique Fernández Molina , Omar Lopez Ocejo , Ricardo de la Caridad Silva Rodriguez , Alexis Musachio Lasa , Ernesto Galban Rodriguez , Dania Marcia Vásquez Blomquist
发明人： Mónica Bequet Romero , Boris Ernesto Acevedo Castro , Jorge Victor Gavilondo Cowley , Luis Enrique Fernández Molina , Omar Lopez Ocejo , Ricardo de la Caridad Silva Rodriguez , Alexis Musachio Lasa , Ernesto Galban Rodriguez , Dania Marcia Vásquez Blomquist
IPC分类号： A61K38/18 , A61K39/395 , C07K14/475 , C07K16/00 , C07K14/515 , C07K14/52 , A61K48/00 , C07K14/71 , C07K14/715 , A61K39/00
CPC分类号： C07K14/715 , A61K38/1858 , A61K38/1866 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/0011 , A61K48/005 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55516 , A61K2039/55594 , C07K14/515 , C07K14/52 , C07K14/71
摘要： Application of oligonucleotide and polypeptide sequences of molecules of the family of the vascular permeability factor (VPF), their receptors, and co-receptors, as well as their modifications, in the active immunotherapy of pathologic entities in which course is associated to the increase of angiogenesis.These procedures can be employed in the single or combined therapy for the treatment of cancer and its metastasis, acute and chronic inflammatory processes, infectious diseases, autoimmune diseases, diabetic and newborn retinopathies, organ transplant rejection, macular degeneration, neovascular glaucoma, hemangioma, and angiofibroma, among others.
摘要翻译： 血管通透性因子（VPF）家族的分子的寡核苷酸和多肽序列在病理实体的主动免疫治疗中的应用及其修饰，其中该过程与增加相关 血管生成。 这些方法可以用于治疗癌症及其转移，急性和慢性炎症过程，感染性疾病，自身免疫性疾病，糖尿病和新生儿视网膜病变，器官移植排斥，黄斑变性，新生血管性青光眼，血管瘤和 血管纤维瘤等。
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7.发明申请PHARMACEUTICAL COMBINATION FOR THE TREATMENT AND OR CHEMOSENSIBILIZATION OF REFRACTORY TUMORS TO ANTICANCER DRUGS 有权用于治疗和/或将抗肿瘤药物化学治疗给药物药物的药物组合公开(公告)号：US20090130228A1
公开(公告)日：2009-05-21
申请号：US12280629
申请日：2007-02-28
申请人： Silvio Ernesto Perea Rodriguez , Yasser Perera Negrin , Arielis Rodriguez Ulloa , Jeovanis Gil Valdes , Yassel Ramos Gomez , Lila Rosa Castellanos Serra , Lazaro Hiram Betancourt Nunez , Aniel Sanchez Puente , Jorge Fernandez de Cossio Dorta Duque , Boris Ernesto Acevedo Castro , Luis Javier Gonzalez Lopez , Vladimir Besada Perez , Daniel Fernando Alonso , Daniel Eduardo Gomez
发明人： Silvio Ernesto Perea Rodriguez , Yasser Perera Negrin , Arielis Rodriguez Ulloa , Jeovanis Gil Valdes , Yassel Ramos Gomez , Lila Rosa Castellanos Serra , Lazaro Hiram Betancourt Nunez , Aniel Sanchez Puente , Jorge Fernandez de Cossio Dorta Duque , Boris Ernesto Acevedo Castro , Luis Javier Gonzalez Lopez , Vladimir Besada Perez , Daniel Fernando Alonso , Daniel Eduardo Gomez
IPC分类号： A61K33/24 , A61K38/08 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/505 , A61K31/704 , A61K31/675 , A61K31/407 , A61K31/4965 , A61K31/506 , A61K31/7088 , A61P35/00
CPC分类号： A61K38/08 , A61K31/136 , A61K31/282 , A61K31/337 , A61K31/407 , A61K31/475 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/555 , A61K31/675 , A61K31/69 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K31/7076 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： This invention is related to a pharmaceutical combination that contains a Casein kinase 2 (CK2) peptide inhibitor (termed P15) along with the standard chemotherapeutic drugs used in cancer treatment and which are administered together, separated or sequentially. The chemothearapeutic drugs include cisplatin, taxol, alkaloids from Vinca, 5-fluorouracil, doxorubicin, cyclophosphamide, etoposide, mitomicin C, imatinib, iressa and velcade (vortezomib). The synergism between the P15 peptide and the anticancer drugs achieves an efficient concentration of each cytostatic drug in the combination which is from 10- to 100-fold lower than that for each cytostatic drug alone. The pharmaceutical combination described in this invention exhibits lower toxicity compared to that reported by the anticancer therapeutics and therefore, it represents a crucial advantage for its use in cancer therapy. Furthermore, the sequential administration of this pharmaceutical combination through the pretreatment with the P15 peptide leads to the chemo sensibilization of refractory tumors to the anticancer therapeutics.
摘要翻译： 本发明涉及含有酪蛋白激酶2（CK2）肽抑制剂（称为P15）以及癌症治疗中使用的标准化学治疗药物并且分开或依次给药的药物组合。 化疗药物包括顺铂，紫杉醇，长春花生物碱，5-氟尿嘧啶，多柔比星，环磷酰胺，依托泊苷，mitomicin C，伊马替尼，iressa和velcade（vortezomib）。 P15肽与抗癌药物之间的协同作用实现了组合中每种细胞抑制药物的有效浓缩，其比单独的每种细胞抑制药物低10至100倍。 本发明中描述的药物组合物与抗癌治疗剂报道的药物组合物相比表现出较低的毒性，因此它代表其用于癌症治疗的关键优势。 此外，通过用P15肽进行预处理，该药物组合的连续施用导致难治性肿瘤对抗癌治疗剂的化学敏感性。
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公开(公告)号：US08748411B2
公开(公告)日：2014-06-10
申请号：US11920031
申请日：2006-05-05
申请人： Rolando Eduardo Rodriguez Fernandez , Roberto Vera Alvarez , Ania De La Nuez Veulens , Yuliet Mazola Reyes , Silvio Ernesto Perea Rodriguez , Boris Ernesto Acevedo Castro , Alexis Musacchio Lasa , Raimundo Ubieta Gómez
发明人： Rolando Eduardo Rodriguez Fernandez , Roberto Vera Alvarez , Ania De La Nuez Veulens , Yuliet Mazola Reyes , Silvio Ernesto Perea Rodriguez , Boris Ernesto Acevedo Castro , Alexis Musacchio Lasa , Raimundo Ubieta Gómez
IPC分类号： A61K31/66 , A61K31/53 , A61K31/505 , A61K31/47 , A61K31/415 , A61K31/40 , C07D251/42 , C07D473/00 , C07D239/02 , C07D215/38 , C07D235/00 , C07D233/96 , C07D209/14 , C07D307/02 , C07D229/00 , C07F9/02 , C07C281/02 , C07C273/02 , C07C303/00 , C07C241/00
CPC分类号： C07C211/14 , C07C237/06 , C07C237/22 , C07C243/28 , C07C255/42 , C07C257/14 , C07C271/22 , C07C271/64 , C07C275/08 , C07C275/16 , C07C275/24 , C07C281/12 , C07C317/28 , C07C327/42 , C07C337/08 , C07D207/34 , C07D209/14 , C07D213/81 , C07D213/82 , C07D215/46 , C07D233/88 , C07D233/91 , C07D235/14 , C07D239/36 , C07D239/46 , C07D239/54 , C07D251/22 , C07D307/52 , C07D487/04 , C07F9/224
摘要： Chemical compounds derived by in silico molecular modelling, having a well defined structure suitable for the blocking of the phosphorylation event, through the specific interaction of the chemical with the Casein Kinase 2 enzyme substrate phosphorylation domain or it's neighbourhood. This invention comprises also the pharmaceutical compositions containing such compounds, and their use in the preparation of medicines or agents for the treatment of diseases or conditions related with neoplasic processes.
摘要翻译： 通过在硅分子模拟中得到的化学化合物通过化学物质与酪蛋白激酶2酶底物磷酸化结构域或其邻域的特异性相互作用具有适合于阻断磷酸化事件的良好定义的结构。 本发明还包含含有这些化合物的药物组合物及其在制备用于治疗与肿瘤过程相关的疾病或病症的药物或试剂中的用途。
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公开(公告)号：US07556809B2
公开(公告)日：2009-07-07
申请号：US10511384
申请日：2003-04-11
申请人： Mónica Bequet Romero , Boris Ernesto Acevedo Castro , Jorge Victor Gavilondo Cowley , Luis Enrique Fernández Molina , Omar Lopez Ocejo , Ricardo de la Caridad Silva Rodriguez , Alexis Musachio Lasa , Ernesto Galban Rodriguez , Dania Marcia Vázquez Blomquist
发明人： Mónica Bequet Romero , Boris Ernesto Acevedo Castro , Jorge Victor Gavilondo Cowley , Luis Enrique Fernández Molina , Omar Lopez Ocejo , Ricardo de la Caridad Silva Rodriguez , Alexis Musachio Lasa , Ernesto Galban Rodriguez , Dania Marcia Vázquez Blomquist
IPC分类号： A61K39/095 , A61K39/39 , A61K38/18 , A61K38/04 , A61K39/395 , C07K4/12
CPC分类号： C07K14/715 , A61K38/1858 , A61K38/1866 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/0011 , A61K48/005 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55516 , A61K2039/55594 , C07K14/515 , C07K14/52 , C07K14/71
摘要： Application of oligonucleotide and polypeptide sequences of molecules of the family of the vascular permeability factor (VPF), their receptors, and co-receptors, as well as their modifications, in the active immunotherapy of pathologic entities in which course is associated to the increase of angiogenesis.These procedures can be employed in the single or combined therapy for the treatment of cancer and its metastasis, acute and chronic inflammatory processes, infectious diseases, autoimmune diseases, diabetic and newborn retinopathies, organ transplant rejection, macular degeneration, neovascular glaucoma, hemangioma, and angiofibroma, among others.
摘要翻译： 血管通透性因子（VPF）家族的分子的寡核苷酸和多肽序列在病理实体的主动免疫治疗中的应用及其修饰，其中该过程与增加相关 血管生成。 这些方法可以用于治疗癌症及其转移，急性和慢性炎症过程，感染性疾病，自身免疫性疾病，糖尿病和新生儿视网膜病变，器官移植排斥，黄斑变性，新生血管性青光眼，血管瘤和 血管纤维瘤等。
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公开(公告)号：US20080254050A1
公开(公告)日：2008-10-16
申请号：US11787522
申请日：2007-04-17
申请人： Monica Bequet Romero , Boris Ernesto Acevedo Castro , Jorge Victor Gavilondo Cowley , Luis Enrique Fernandez Molina , Omar Lopez Ocejo , Ricardo de la Caridad Silva Rodriguez , Alexis Musachio Lasa , Ernesto Galban Rodriguez , Dania Marcia Vazquez Blomquist
发明人： Monica Bequet Romero , Boris Ernesto Acevedo Castro , Jorge Victor Gavilondo Cowley , Luis Enrique Fernandez Molina , Omar Lopez Ocejo , Ricardo de la Caridad Silva Rodriguez , Alexis Musachio Lasa , Ernesto Galban Rodriguez , Dania Marcia Vazquez Blomquist
CPC分类号： C07K14/715 , A61K38/1858 , A61K38/1866 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/0011 , A61K48/005 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55516 , A61K2039/55594 , C07K14/515 , C07K14/52 , C07K14/71
摘要： Application of oligonucleotide and polypeptide sequences of molecules of the family of the vascular permeability factor (VPF), their receptors, and co-receptors, as well as their modifications, in the active immunotherapy of pathologic entities in which course is associated to the increase of angiogenesis.These procedures can be employed in the single or combined therapy for the treatment of cancer and its metastasis, acute and chronic inflammatory processes, infectious diseases, autoimmune diseases, diabetic and newborn retinopathies, organ transplant rejection, macular degeneration, neovascular glaucoma, hemangioma, and angiofibroma, among others.
摘要翻译： 血管通透性因子（VPF）家族的分子的寡核苷酸和多肽序列在病理实体的主动免疫治疗中的应用及其修饰，其中该过程与增加相关 血管生成。 这些方法可以用于治疗癌症及其转移，急性和慢性炎症过程，感染性疾病，自身免疫性疾病，糖尿病和新生儿视网膜病变，器官移植排斥，黄斑变性，新生血管性青光眼，血管瘤和 血管纤维瘤等。
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