Invention Application
- Patent Title: DNA Damage Repair Inhibitors for the Treatment of Cancer
- Patent Title (中): DNA损伤修复抑制剂治疗癌症
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Application No.: US13286475Application Date: 2011-11-01
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Publication No.: US20120135983A1Publication Date: 2012-05-31
- Inventor: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith
- Applicant: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith
- Assignee: The Institute of Cancer Reseach,Kudos Pharmaceuticals Limited,Royal Cancer Hospital
- Current Assignee: The Institute of Cancer Reseach,Kudos Pharmaceuticals Limited,Royal Cancer Hospital
- Priority: GB0327844.7 20031201
- Main IPC: A61K31/551
- IPC: A61K31/551 ; A61P35/00 ; G01N33/566 ; C12Q1/06 ; A61K31/502 ; C12Q1/68
Abstract:
The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
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