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公开(公告)号:US08799250B1
公开(公告)日:2014-08-05
申请号:US11961892
申请日:2007-12-20
Applicant: Graeme Smith , Matthew J. Round , Andrew Birkett , Elinor Trotter , Michael Davidson , Gregory Huczynski , Jason King , Haakon Sorensen , Jason Kilar
Inventor: Graeme Smith , Matthew J. Round , Andrew Birkett , Elinor Trotter , Michael Davidson , Gregory Huczynski , Jason King , Haakon Sorensen , Jason Kilar
CPC classification number: G06F17/3097 , G06F17/30648 , G06F17/30867 , G06Q30/02 , G06Q30/06
Abstract: A method and system are disclosed for allowing a user to suggest information about content that can be utilized in processing subsequent searches. The suggested information may be different from a fixed set of information about an item, such as keywords, attributes, or characteristics of an item, generally provided by a manufacturer or seller of the item. Users can submit to a service the information that they feel is relevant to the item, such as a brief explanation of relevance and a detailed explanation that would help other users to make a decision about the item. The submitted information may be associated with the item information and stored in a data store and utilized as additional attributes of the item for a search. In addition, when a user requests detail information about an item, the user-submitted information may be displayed to the user.
Abstract translation: 公开了一种方法和系统,用于允许用户建议关于可用于处理后续搜索的内容的信息。 建议的信息可以不同于关于项目的一系列固定信息,例如关键字,属性或项目的特征,通常由该制品的制造者或卖方提供。 用户可以向服务提交他们认为与项目相关的信息,例如相关性的简短说明以及有助于其他用户对该项目做出决定的详细说明。 提交的信息可以与项目信息相关联并存储在数据存储中,并且用作用于搜索的项目的附加属性。 此外,当用户请求有关项目的详细信息时,用户提交的信息可以显示给用户。
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公开(公告)号:US20080081809A1
公开(公告)日:2008-04-03
申请号:US11842930
申请日:2007-08-21
Applicant: Heather Duggan , Karine Malagu , Frederic Leroux , Niall Martin , Keith Menear , Graeme Smith
Inventor: Heather Duggan , Karine Malagu , Frederic Leroux , Niall Martin , Keith Menear , Graeme Smith
IPC: A61K31/5377 , A61P35/00 , C07D413/02 , C07D413/14
CPC classification number: A61K31/5377 , A61K31/565 , A61K45/06 , C07D413/14 , C07D471/04 , C07D475/08 , C07D475/10
Abstract: There is provided a compound of formula I: , or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.
Abstract translation: 提供式I化合物或其药学上可接受的盐。 还提供了制备式1化合物的方法和式1化合物作为药物和用于治疗癌症的用途。
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公开(公告)号:US20070143577A1
公开(公告)日:2007-06-21
申请号:US11669537
申请日:2007-01-31
Applicant: Graeme Smith
Inventor: Graeme Smith
IPC: G06F15/00
CPC classification number: G06F15/7867 , H03K19/177 , H03K19/17752 , H03K19/17756 , Y02D10/12 , Y02D10/13
Abstract: A reconfigurable integrated circuit is provided wherein the available hardware resources can be optimised for a particular application. Dynamically reconfiguring (in both real-time and non real-time) the available resources and sharing a plurality of processing elements with a plurality of controller elements achieve this. In a preferred embodiment the integrated circuit includes a plurality of processing blocks, which interface to a reconfigurable interconnection means. A processing block has two forms, namely a shared resource block and a dedicated resource block. Each processing block consists of one or a plurality of controller elements and a plurality of processing elements. The controller element and processing element generally comprise diverse rigid coarse and fine grained circuits and are interconnected through dedicated and reconfigurable interconnect. The processing blocks can be configured as a hierarchy of blocks and or fractal architecture.
Abstract translation: 提供了一种可重构集成电路,其中可针对特定应用优化可用的硬件资源。 动态重新配置(实时和非实时)可用资源并与多个控制器元件共享多个处理元件实现这一点。 在优选实施例中,集成电路包括多个处理块,其与可重新配置的互连装置接口。 处理块具有两种形式,即共享资源块和专用资源块。 每个处理块由一个或多个控制器元件和多个处理元件组成。 控制器元件和处理元件通常包括不同的刚性粗糙和细粒度电路,并且通过专用和可重新配置的互连互连。 处理块可以被配置为块和/或分形结构的层次结构。
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公开(公告)号:US20060149059A1
公开(公告)日:2006-07-06
申请号:US11318155
申请日:2005-12-23
Applicant: Niall Martin , Graeme Smith , Stephen Jackson , Vincent Loh , Xiao-Ling Cockcroft , Ian Matthews , Keith Menear , Frank Kerrigan , Alan Ashworth
Inventor: Niall Martin , Graeme Smith , Stephen Jackson , Vincent Loh , Xiao-Ling Cockcroft , Ian Matthews , Keith Menear , Frank Kerrigan , Alan Ashworth
IPC: C07D403/02 , A61K31/502
CPC classification number: A61K31/00 , C07D237/32 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/04 , C07D495/04
Abstract: Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X=NRX then n is 1 or 2 and if X=CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.
Abstract translation: 式(I)的化合物:其中A和B一起表示任选取代的稠合芳环; X可以是NR X或X X R O Y; 如果X = NR X,则n为1或2,并且如果X = CR X R Y Y,则n为1; R X选自H,任选取代的C 1-20烷基,C 5-20-20芳基,C 1〜 酰胺基,磺酰基,磺酰基,酰基和磺酰基; R Y选自H,羟基,氨基; 或R X和R Y可以一起形成螺C 3-7环烷基或杂环基; R C1和R C2都是氢,或者当X是CR X R Y,R O, C 1,R 2,R 2,X和R Y以及它们所连接的碳原子可以形成 任选取代的稠合芳环; R 1和R 2选自H和卤素。
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公开(公告)号:US20060014530A1
公开(公告)日:2006-01-19
申请号:US10892769
申请日:2004-07-16
Applicant: Lawrence Denenberg , Harry Forsdick , Michael Krasner , Graeme Smith , Grant Gould , Marc Neuberger , Marc Tanner
Inventor: Lawrence Denenberg , Harry Forsdick , Michael Krasner , Graeme Smith , Grant Gould , Marc Neuberger , Marc Tanner
IPC: H04Q7/20
CPC classification number: H04L51/10 , H04L12/18 , H04L12/2854 , H04L51/00 , H04L51/04 , H04L51/066 , H04L51/38 , H04L63/10 , H04L67/04 , H04L67/24 , H04L67/42 , H04L69/329
Abstract: A personal server is provided for use with a mobile device, such as a cellular telephone. The personal server provides services to the user of the mobile device and to others authorized by the user, but to no other users. The personal server may be a home PC of the user of the mobile device. The personal server may serve as a proxy server for a shared server that provides services to the mobile device. The personal server may relay messages between the mobile device and the shared server. The personal server may store, log, filter, and perform other processing on the user's personal data, such as messages transmitted by the mobile device and/or the shared server. The personal server may aggregate messages received from a plurality of shared servers. A non-personal server may perform additional services, such as configuring the personal server and temporarily storing data if the personal server becomes inaccessible.
Abstract translation: 提供个人服务器用于诸如蜂窝电话的移动设备。 个人服务器向移动设备的用户和用户授权的用户提供服务,但不向其他用户提供服务。 个人服务器可以是移动设备的用户的家庭PC。 个人服务器可以用作向移动设备提供服务的共享服务器的代理服务器。 个人服务器可以在移动设备和共享服务器之间转发消息。 个人服务器可以存储,登录,过滤和对用户的个人数据执行其他处理,诸如由移动设备和/或共享服务器发送的消息。 个人服务器可以聚合从多个共享服务器接收的消息。 非个人服务器可以执行附加服务,例如配置个人服务器,并且如果个人服务器变得不可访问,则临时存储数据。
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公开(公告)号:US20050227919A1
公开(公告)日:2005-10-13
申请号:US11001474
申请日:2004-11-30
Applicant: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith
Inventor: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith
IPC: A61K31/00 , A61K31/366 , A61K31/405 , A61K31/4184 , A61K31/4706 , A61K31/473 , A61K31/502 , A61K31/517 , A61K31/522 , A61K31/675 , A61K38/54 , A61K48/00
CPC classification number: A61K31/366 , A61K31/00 , A61K31/405 , A61K31/4184 , A61K31/4706 , A61K31/473 , A61K31/502 , A61K31/517 , A61K31/522 , A61K31/675 , Y02A50/473
Abstract: The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
Abstract translation: 本发明涉及对在HR依赖性DNA DSB修复缺陷的细胞中碱基切除修复途径的抑制选择性致死的认识。 本文提供了使用靶向基础切除修复组分(如PARP)的抑制剂治疗缺乏HR依赖性DNA DSB修复的癌症治疗方法和手段。
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7.
公开(公告)号:US20120135983A1
公开(公告)日:2012-05-31
申请号:US13286475
申请日:2011-11-01
Applicant: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith
Inventor: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith
IPC: A61K31/551 , A61P35/00 , G01N33/566 , C12Q1/06 , A61K31/502 , C12Q1/68
CPC classification number: A61K31/366 , A61K31/00 , A61K31/405 , A61K31/4184 , A61K31/4706 , A61K31/473 , A61K31/502 , A61K31/517 , A61K31/522 , A61K31/675 , Y02A50/473
Abstract: The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
Abstract translation: 本发明涉及对在HR依赖性DNA DSB修复缺陷的细胞中碱基切除修复途径的抑制选择性致死的认识。 本文提供了使用靶向基础切除修复组分(如PARP)的抑制剂治疗缺乏HR依赖性DNA DSB修复的癌症治疗方法和手段。
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公开(公告)号:US20060264623A1
公开(公告)日:2006-11-23
申请号:US11403763
申请日:2006-04-13
Applicant: Graeme Smith , Niall Martin , Keith Menear , Marc Hummersone , Xiao-ling Cockcroft , Mark Frigerio , Roger Griffin , Bernard Golding , Ian Hardcastle , David Newell , Hilary Calvert , Nicola Curtin , Marine Desage-El Murr
Inventor: Graeme Smith , Niall Martin , Keith Menear , Marc Hummersone , Xiao-ling Cockcroft , Mark Frigerio , Roger Griffin , Bernard Golding , Ian Hardcastle , David Newell , Hilary Calvert , Nicola Curtin , Marine Desage-El Murr
IPC: C07D413/00
CPC classification number: C07D413/00 , C07D401/14 , C07D405/04 , C07D407/04 , C07D407/14 , C07D409/04 , C07D471/04
Abstract: Compounds of formula l: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N;and (iii) CH, O, C; are disclosed for use in inhibiting DNA-PK.
Abstract translation: 式I化合物:其中A,B和D分别选自:(i)CH,NH,C; (ii)CH,N,N;和(iii)CH,O,C; 被公开用于抑制DNA-PK。
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公开(公告)号:US20060178361A1
公开(公告)日:2006-08-10
申请号:US11351052
申请日:2006-02-09
Applicant: Marc Hummersone , Keith Menear , Laurent Rigoreau , Graeme Smith , Niall Martin , Roger Griffin
Inventor: Marc Hummersone , Keith Menear , Laurent Rigoreau , Graeme Smith , Niall Martin , Roger Griffin
IPC: A61K31/55 , A61K31/453 , C07D409/14
CPC classification number: C07D409/04 , C07D409/14
Abstract: A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 together form, along with the nitrogen atom to which they are attached, an optionally substituted nitrogen containing heterocyclic ring having from 4 to 8 ring atoms; and R3 is selected from hydroxy and —NRN1RN2, where RN1 and RN2 are independently selected from hydrogen, optionally substituted C1-7 alkyl groups, optionally substituted C3-20 heterocyclyl groups and optionally substituted C5-20 aryl groups, or together form, along with the nitrogen atom to which they are attached, an optionally substituted nitrogen containing heterocyclic ring having from 4 to 8 ring atoms, and its use in inhibiting ATM.
Abstract translation: 式I化合物及其异构体,盐,溶剂化物,化学保护形式及其前药,其中:R 1和R 2一起与氮原子一起形成 它们所连接的是具有4-8个环原子的任选取代的含氮杂环; R 3和R 3选自羟基和-NR N 1 N 2 N 2,其中R 11和R 10独立地选自氢, N 2独立地选自氢,任选取代的C 1-7烷基,任选取代的C 3-20杂环基和任选取代的C 5 -20个芳基,或者与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的含氮杂环,以及其在抑制ATM中的用途。
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公开(公告)号:US20060142293A1
公开(公告)日:2006-06-29
申请号:US11352178
申请日:2006-02-10
Applicant: Niall Martin , Graeme Smith , Charles White , Roger Newton , Diane Douglas , Penny Eversley , Julia Vile
Inventor: Niall Martin , Graeme Smith , Charles White , Roger Newton , Diane Douglas , Penny Eversley , Julia Vile
IPC: A61K31/502
CPC classification number: C07D401/12 , A61K31/50 , A61K31/502 , C07D237/32 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: A method of treatment of a disease of the human or animal body mediated by PARP comprising administering to such a subject a therapeutically effective amount of a compound of formula: or an isomer, salt, solvate, chemically protected form, and prodrug thereof, wherein: A and B together represent an optionally substituted, fused aromatic ring; RC is represented by -L-RL, where L is of formula: —(CH2)n1-Qn2-(CH2)n3— wherein n1, n2 and n3 are each selected from 0, 1, 2 and 3, the sum of n1, n2 and n3 is 1, 2 or 3 and Q is selected from O, S, NH, C(═O) or —CR1R2—, where R1 and R2 are independently selected from hydrogen, halogen or optionally substituted C1-7 alkyl, or may together with the carbon atom to which they are attached form a C3-7 cyclic alkyl group, which may be saturated (a C3-7 cycloalkyl group) or unsaturated (a C3-7 cycloalkenyl group), or one of R1 and R2 may be attached to an atom in RL to form an unsaturated C3-7 cycloalkenyl group which comprises the carbon atoms to which R1 and R2 are attached in Q, —(CH2)n3— (if present) and part of RL; and RL is optionally substituted C5-20 aryl; and RN is selected from hydrogen, optionally substituted C1-7 alkyl, C3-20 heterocyclyl, and C5-20 aryl, hydroxy, ether, nitro, amino, amido, thiol, thioether, sulfoxide and sulfone.
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