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公开(公告)号:US08661007B1
公开(公告)日:2014-02-25
申请号:US11961892
申请日:2007-12-20
申请人: Graeme Smith , Matt Round , Andrew Birkett , Elinor Trotter , Michael Davidson , Gregory Huczynski , Jason King , Haakon Sorensen , Jason Kilar
发明人: Graeme Smith , Matt Round , Andrew Birkett , Elinor Trotter , Michael Davidson , Gregory Huczynski , Jason King , Haakon Sorensen , Jason Kilar
摘要: A method and system are disclosed for allowing a user to suggest information about content that can be utilized in processing subsequent searches. The suggested information may be different from a fixed set of information about an item, such as keywords, attributes, or characteristics of an item, generally provided by a manufacturer or seller of the item. Users can submit to a service the information that they feel is relevant to the item, such as a brief explanation of relevance and a detailed explanation that would help other users to make a decision about the item. The submitted information may be associated with the item information and stored in a data store and utilized as additional attributes of the item for a search. In addition, when a user requests detail information about an item, the user-submitted information may be displayed to the user.
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公开(公告)号:US20130254114A1
公开(公告)日:2013-09-26
申请号:US13428623
申请日:2012-03-23
申请人: Graeme Smith
发明人: Graeme Smith
CPC分类号: G06Q30/06 , G06Q20/20 , G06Q20/201 , G06Q20/208 , G06Q20/3274 , G06Q20/3276 , G07G1/0054
摘要: Techniques for network-based self-checkout are provided. A consumer of an establishment uses a mobile app to self-scan barcodes of items for purchase. A running list of the items is maintained by a network shopping manager. The consumer uses the app to purchase the items when desired and the shopping manager sends a code to the app to validate the purchase. When exiting the establishment, the app provides the code to a self-service checkout system and as the customer bags the items, each item is validated against the list without requiring any additional action on the part of the consumer.
摘要翻译: 提供了基于网络的自检功能。 企业的消费者使用移动应用程序自行扫描要购买的物品的条形码。 项目的运行列表由网络购物经理维护。 消费者使用应用程序在需要时购买项目,购物经理将代码发送到应用程序以验证购买。 当退出企业时,应用程序将代码提供给自助结帐系统,并且随着客户包装物品,每个项目都对该列表进行验证,而不需要对消费者进行任何额外的操作。
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公开(公告)号:US20070238729A1
公开(公告)日:2007-10-11
申请号:US11758332
申请日:2007-06-05
申请人: Niall Martin , Graeme Smith , Roger Griffin , Bernard Golding , Ian Hardcastle , David Newell , Hilary Calvert , Nicola Curtin , Laurent Rigoreau , Xiao-ling Cockcroft , Vincent Junior Loh , Paul Workman , Florence Raynaud , Bernard Nutley
发明人: Niall Martin , Graeme Smith , Roger Griffin , Bernard Golding , Ian Hardcastle , David Newell , Hilary Calvert , Nicola Curtin , Laurent Rigoreau , Xiao-ling Cockcroft , Vincent Junior Loh , Paul Workman , Florence Raynaud , Bernard Nutley
IPC分类号: A61K31/351 , A61K31/519 , A61K31/5377 , A61P35/00
CPC分类号: C07D417/04 , C07D309/38 , C07D311/22 , C07D311/92 , C07D471/04
摘要: The invention relates to the use of compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, in the preparation of a medicament for inhibiting the activity of DNA-PK, wherein R1 and R2 are independently hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; X and Y are selected from CR4 and O, O and CR′4 and NR″4 and N, where the unsaturation is in the appropriate place in the ring, and where one of R3 and R4 or R′4 is an optionally substituted C3-20 heteroaryl or C5-20 aryl group, and the other of R3 and R4 or R′4 is H, or R3 and R4 or R″4 together are -A-B—, which collectively represent a fused optionally substituted aromatic ring. The compounds also selectively inhibit the activity of DNA-PK compared to PI 3-kinase and/or ATM.
摘要翻译: 本发明涉及式(I)化合物及其异构体,盐,溶剂合物,化学保护形式及其前药在制备用于抑制DNA-PK活性的药物中的用途,其中R 1, R 2和R 2各自独立地为氢,任选取代的C 1-7 - 烷基,C 3-20杂环基或C 或者可以与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; X和Y选自CR 4和O,O和CR'4和NR“4和N,其中不饱和键处于 R 2中的一个是R 3,R 4,R 4和R 4中的一个是任选取代的C 3 -20个杂芳基或C 5-20-20芳基,R 3和R 4中的另一个或R' > 4 SUP>是H,或R 3和R 4或R“4”一起是-AB-,它们共同表示 稠合的任选取代的芳环。 与PI3-激酶和/或ATM相比,化合物还选择性地抑制DNA-PK的活性。
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公开(公告)号:US20070049588A1
公开(公告)日:2007-03-01
申请号:US11468315
申请日:2006-08-30
申请人: Graeme Smith , Niall Martin , Andrew Slade , Keith Menear , Marc Hummersone , Xiao-Ling Cockcroft , Ian Matthews , Laurent Rigoreau , Roger Griffin , David Newell , Nicola Curtin
发明人: Graeme Smith , Niall Martin , Andrew Slade , Keith Menear , Marc Hummersone , Xiao-Ling Cockcroft , Ian Matthews , Laurent Rigoreau , Roger Griffin , David Newell , Nicola Curtin
IPC分类号: A61K31/5377 , C07D413/14
CPC分类号: C07D409/04
摘要: A compound of formula (I): and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, and their use in treating diseases ameliorated by the inhibition of ATM.
摘要翻译: 式(I)的化合物及其异构体,盐,溶剂化物,化学保护形式及其前药,以及它们在治疗通过抑制ATM而改善的疾病中的用途。
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公开(公告)号:US20060264427A1
公开(公告)日:2006-11-23
申请号:US11403606
申请日:2006-04-13
申请人: Graeme Smith , Niall Martin , Keith Menear , Marc Hummersone , Xiao-ling Cockcroft , Mark Frigerio , Roger Griffin , Bernard Golding , Ian Hardcastle , David Newell , HiIary Calvert , Nicola Curtin , Kappusamy Saravanan , Marine Desage-El Murr
发明人: Graeme Smith , Niall Martin , Keith Menear , Marc Hummersone , Xiao-ling Cockcroft , Mark Frigerio , Roger Griffin , Bernard Golding , Ian Hardcastle , David Newell , HiIary Calvert , Nicola Curtin , Kappusamy Saravanan , Marine Desage-El Murr
IPC分类号: A61K31/541 , A61K31/5377 , C07D487/02
CPC分类号: C07D413/00 , C07D401/14 , C07D405/04 , C07D407/04 , C07D407/14 , C07D409/04 , C07D471/04
摘要: Compounds of formula I: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N;and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; and where Z is selected from S, O, C(═O), CH2 and NH are disclosed for use in inhibiting DNA-PK.
摘要翻译: 式I化合物:其中A,B和D分别选自:(i)CH,NH,C; (ii)CH,N,N;和(iii)CH,O,C; 虚线表示适当位置的两个双键; 并且其中Z选自S,O,C(-O),CH 2和NH,用于抑制DNA-PK。
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公开(公告)号:US20120135983A1
公开(公告)日:2012-05-31
申请号:US13286475
申请日:2011-11-01
申请人: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith
发明人: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith
IPC分类号: A61K31/551 , A61P35/00 , G01N33/566 , C12Q1/06 , A61K31/502 , C12Q1/68
CPC分类号: A61K31/366 , A61K31/00 , A61K31/405 , A61K31/4184 , A61K31/4706 , A61K31/473 , A61K31/502 , A61K31/517 , A61K31/522 , A61K31/675 , Y02A50/473
摘要: The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
摘要翻译: 本发明涉及对在HR依赖性DNA DSB修复缺陷的细胞中碱基切除修复途径的抑制选择性致死的认识。 本文提供了使用靶向基础切除修复组分(如PARP)的抑制剂治疗缺乏HR依赖性DNA DSB修复的癌症治疗方法和手段。
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公开(公告)号:US20060264623A1
公开(公告)日:2006-11-23
申请号:US11403763
申请日:2006-04-13
申请人: Graeme Smith , Niall Martin , Keith Menear , Marc Hummersone , Xiao-ling Cockcroft , Mark Frigerio , Roger Griffin , Bernard Golding , Ian Hardcastle , David Newell , Hilary Calvert , Nicola Curtin , Marine Desage-El Murr
发明人: Graeme Smith , Niall Martin , Keith Menear , Marc Hummersone , Xiao-ling Cockcroft , Mark Frigerio , Roger Griffin , Bernard Golding , Ian Hardcastle , David Newell , Hilary Calvert , Nicola Curtin , Marine Desage-El Murr
IPC分类号: C07D413/00
CPC分类号: C07D413/00 , C07D401/14 , C07D405/04 , C07D407/04 , C07D407/14 , C07D409/04 , C07D471/04
摘要: Compounds of formula l: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N;and (iii) CH, O, C; are disclosed for use in inhibiting DNA-PK.
摘要翻译: 式I化合物:其中A,B和D分别选自:(i)CH,NH,C; (ii)CH,N,N;和(iii)CH,O,C; 被公开用于抑制DNA-PK。
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公开(公告)号:US20060178361A1
公开(公告)日:2006-08-10
申请号:US11351052
申请日:2006-02-09
申请人: Marc Hummersone , Keith Menear , Laurent Rigoreau , Graeme Smith , Niall Martin , Roger Griffin
发明人: Marc Hummersone , Keith Menear , Laurent Rigoreau , Graeme Smith , Niall Martin , Roger Griffin
IPC分类号: A61K31/55 , A61K31/453 , C07D409/14
CPC分类号: C07D409/04 , C07D409/14
摘要: A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 together form, along with the nitrogen atom to which they are attached, an optionally substituted nitrogen containing heterocyclic ring having from 4 to 8 ring atoms; and R3 is selected from hydroxy and —NRN1RN2, where RN1 and RN2 are independently selected from hydrogen, optionally substituted C1-7 alkyl groups, optionally substituted C3-20 heterocyclyl groups and optionally substituted C5-20 aryl groups, or together form, along with the nitrogen atom to which they are attached, an optionally substituted nitrogen containing heterocyclic ring having from 4 to 8 ring atoms, and its use in inhibiting ATM.
摘要翻译: 式I化合物及其异构体,盐,溶剂化物,化学保护形式及其前药,其中:R 1和R 2一起与氮原子一起形成 它们所连接的是具有4-8个环原子的任选取代的含氮杂环; R 3和R 3选自羟基和-NR N 1 N 2 N 2,其中R 11和R 10独立地选自氢, N 2独立地选自氢,任选取代的C 1-7烷基,任选取代的C 3-20杂环基和任选取代的C 5 -20个芳基,或者与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的含氮杂环,以及其在抑制ATM中的用途。
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公开(公告)号:US20060142293A1
公开(公告)日:2006-06-29
申请号:US11352178
申请日:2006-02-10
申请人: Niall Martin , Graeme Smith , Charles White , Roger Newton , Diane Douglas , Penny Eversley , Julia Vile
发明人: Niall Martin , Graeme Smith , Charles White , Roger Newton , Diane Douglas , Penny Eversley , Julia Vile
IPC分类号: A61K31/502
CPC分类号: C07D401/12 , A61K31/50 , A61K31/502 , C07D237/32 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: A method of treatment of a disease of the human or animal body mediated by PARP comprising administering to such a subject a therapeutically effective amount of a compound of formula: or an isomer, salt, solvate, chemically protected form, and prodrug thereof, wherein: A and B together represent an optionally substituted, fused aromatic ring; RC is represented by -L-RL, where L is of formula: —(CH2)n1-Qn2-(CH2)n3— wherein n1, n2 and n3 are each selected from 0, 1, 2 and 3, the sum of n1, n2 and n3 is 1, 2 or 3 and Q is selected from O, S, NH, C(═O) or —CR1R2—, where R1 and R2 are independently selected from hydrogen, halogen or optionally substituted C1-7 alkyl, or may together with the carbon atom to which they are attached form a C3-7 cyclic alkyl group, which may be saturated (a C3-7 cycloalkyl group) or unsaturated (a C3-7 cycloalkenyl group), or one of R1 and R2 may be attached to an atom in RL to form an unsaturated C3-7 cycloalkenyl group which comprises the carbon atoms to which R1 and R2 are attached in Q, —(CH2)n3— (if present) and part of RL; and RL is optionally substituted C5-20 aryl; and RN is selected from hydrogen, optionally substituted C1-7 alkyl, C3-20 heterocyclyl, and C5-20 aryl, hydroxy, ether, nitro, amino, amido, thiol, thioether, sulfoxide and sulfone.
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公开(公告)号:US20060142231A1
公开(公告)日:2006-06-29
申请号:US11245735
申请日:2005-10-06
申请人: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith , Mark O'Connor
发明人: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith , Mark O'Connor
IPC分类号: A61K48/00 , A61K31/522 , A61K31/502 , A61K31/473 , A61K31/517 , A61K31/4704 , A61K31/4035 , A61K31/366
CPC分类号: A61K31/366 , A61K31/405 , A61K31/4184 , A61K31/4706 , A61K31/473 , A61K31/502 , A61K31/517 , A61K31/522 , A61K31/675 , Y02A50/473
摘要: DNA Damage Repair Inhibitors for Treatment of Cancer The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
摘要翻译: 用于治疗癌症的DNA损伤修复抑制剂本发明涉及对在HR依赖性DNA DSB修复缺陷的细胞中碱基切除修复途径的抑制选择性致死的认识。 本文提供了使用靶向基础切除修复组分(如PARP)的抑制剂治疗缺乏HR依赖性DNA DSB修复的癌症治疗方法和手段。
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