公开(公告)号：US08799250B1

公开(公告)日：2014-08-05

申请号：US11961892

申请日：2007-12-20

申请人： Graeme Smith ,  Matthew J. Round ,  Andrew Birkett ,  Elinor Trotter ,  Michael Davidson ,  Gregory Huczynski ,  Jason King ,  Haakon Sorensen ,  Jason Kilar

发明人： Graeme Smith ,  Matthew J. Round ,  Andrew Birkett ,  Elinor Trotter ,  Michael Davidson ,  Gregory Huczynski ,  Jason King ,  Haakon Sorensen ,  Jason Kilar

IPC分类号： G06F7/00 ,  G06F17/30 ,  G06Q30/02

CPC分类号： G06F17/3097 ,  G06F17/30648 ,  G06F17/30867 ,  G06Q30/02 ,  G06Q30/06

摘要： A method and system are disclosed for allowing a user to suggest information about content that can be utilized in processing subsequent searches. The suggested information may be different from a fixed set of information about an item, such as keywords, attributes, or characteristics of an item, generally provided by a manufacturer or seller of the item. Users can submit to a service the information that they feel is relevant to the item, such as a brief explanation of relevance and a detailed explanation that would help other users to make a decision about the item. The submitted information may be associated with the item information and stored in a data store and utilized as additional attributes of the item for a search. In addition, when a user requests detail information about an item, the user-submitted information may be displayed to the user.

摘要翻译： 公开了一种方法和系统，用于允许用户建议关于可用于处理后续搜索的内容的信息。 建议的信息可以不同于关于项目的一系列固定信息，例如关键字，属性或项目的特征，通常由该制品的制造者或卖方提供。 用户可以向服务提交他们认为与项目相关的信息，例如相关性的简短说明以及有助于其他用户对该项目做出决定的详细说明。 提交的信息可以与项目信息相关联并存储在数据存储中，并且用作用于搜索的项目的附加属性。 此外，当用户请求有关项目的详细信息时，用户提交的信息可以显示给用户。

公开(公告)号：US20080081809A1

公开(公告)日：2008-04-03

申请号：US11842930

申请日：2007-08-21

申请人： Heather Duggan ,  Karine Malagu ,  Frederic Leroux ,  Niall Martin ,  Keith Menear ,  Graeme Smith

发明人： Heather Duggan ,  Karine Malagu ,  Frederic Leroux ,  Niall Martin ,  Keith Menear ,  Graeme Smith

IPC分类号： A61K31/5377 ,  A61P35/00 ,  C07D413/02 ,  C07D413/14

CPC分类号： A61K31/5377 ,  A61K31/565 ,  A61K45/06 ,  C07D413/14 ,  C07D471/04 ,  C07D475/08 ,  C07D475/10

摘要： There is provided a compound of formula I: , or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.

摘要翻译： 提供式I化合物或其药学上可接受的盐。 还提供了制备式1化合物的方法和式1化合物作为药物和用于治疗癌症的用途。

公开(公告)号：US20070143577A1

公开(公告)日：2007-06-21

申请号：US11669537

申请日：2007-01-31

申请人： Graeme Smith

发明人： Graeme Smith

IPC分类号： G06F15/00

CPC分类号： G06F15/7867 ,  H03K19/177 ,  H03K19/17752 ,  H03K19/17756 ,  Y02D10/12 ,  Y02D10/13

摘要： A reconfigurable integrated circuit is provided wherein the available hardware resources can be optimised for a particular application. Dynamically reconfiguring (in both real-time and non real-time) the available resources and sharing a plurality of processing elements with a plurality of controller elements achieve this. In a preferred embodiment the integrated circuit includes a plurality of processing blocks, which interface to a reconfigurable interconnection means. A processing block has two forms, namely a shared resource block and a dedicated resource block. Each processing block consists of one or a plurality of controller elements and a plurality of processing elements. The controller element and processing element generally comprise diverse rigid coarse and fine grained circuits and are interconnected through dedicated and reconfigurable interconnect. The processing blocks can be configured as a hierarchy of blocks and or fractal architecture.

摘要翻译： 提供了一种可重构集成电路，其中可针对特定应用优化可用的硬件资源。 动态重新配置（实时和非实时）可用资源并与多个控制器元件共享多个处理元件实现这一点。 在优选实施例中，集成电路包括多个处理块，其与可重新配置的互连装置接口。 处理块具有两种形式，即共享资源块和专用资源块。 每个处理块由一个或多个控制器元件和多个处理元件组成。 控制器元件和处理元件通常包括不同的刚性粗糙和细粒度电路，并且通过专用和可重新配置的互连互连。 处理块可以被配置为块和/或分形结构的层次结构。

公开(公告)号：US20060149059A1

公开(公告)日：2006-07-06

申请号：US11318155

申请日：2005-12-23

申请人： Niall Martin ,  Graeme Smith ,  Stephen Jackson ,  Vincent Loh ,  Xiao-Ling Cockcroft ,  Ian Matthews ,  Keith Menear ,  Frank Kerrigan ,  Alan Ashworth

发明人： Niall Martin ,  Graeme Smith ,  Stephen Jackson ,  Vincent Loh ,  Xiao-Ling Cockcroft ,  Ian Matthews ,  Keith Menear ,  Frank Kerrigan ,  Alan Ashworth

IPC分类号： C07D403/02 ,  A61K31/502

CPC分类号： A61K31/00 ,  C07D237/32 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D491/04 ,  C07D495/04

摘要： Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X=NRX then n is 1 or 2 and if X=CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.

摘要翻译： 式（I）的化合物：其中A和B一起表示任选取代的稠合芳环; X可以是NR X或X X R O Y; 如果X = NR X，则n为1或2，并且如果X = CR X R Y Y，则n为1; R X选自H，任选取代的C 1-20烷基，C 5-20-20芳基，C 1〜 酰胺基，磺酰基，磺酰基，酰基和磺酰基; R Y选自H，羟基，氨基; 或R X和R Y可以一起形成螺C 3-7环烷基或杂环基; R C1和R C2都是氢，或者当X是CR X R Y，R O， C 1，R 2，R 2，X和R Y以及它们所连接的碳原子可以形成 任选取代的稠合芳环; R 1和R 2选自H和卤素。

公开(公告)号：US20060014530A1

公开(公告)日：2006-01-19

申请号：US10892769

申请日：2004-07-16

申请人： Lawrence Denenberg ,  Harry Forsdick ,  Michael Krasner ,  Graeme Smith ,  Grant Gould ,  Marc Neuberger ,  Marc Tanner

发明人： Lawrence Denenberg ,  Harry Forsdick ,  Michael Krasner ,  Graeme Smith ,  Grant Gould ,  Marc Neuberger ,  Marc Tanner

IPC分类号： H04Q7/20

CPC分类号： H04L51/10 ,  H04L12/18 ,  H04L12/2854 ,  H04L51/00 ,  H04L51/04 ,  H04L51/066 ,  H04L51/38 ,  H04L63/10 ,  H04L67/04 ,  H04L67/24 ,  H04L67/42 ,  H04L69/329

摘要： A personal server is provided for use with a mobile device, such as a cellular telephone. The personal server provides services to the user of the mobile device and to others authorized by the user, but to no other users. The personal server may be a home PC of the user of the mobile device. The personal server may serve as a proxy server for a shared server that provides services to the mobile device. The personal server may relay messages between the mobile device and the shared server. The personal server may store, log, filter, and perform other processing on the user's personal data, such as messages transmitted by the mobile device and/or the shared server. The personal server may aggregate messages received from a plurality of shared servers. A non-personal server may perform additional services, such as configuring the personal server and temporarily storing data if the personal server becomes inaccessible.

摘要翻译： 提供个人服务器用于诸如蜂窝电话的移动设备。 个人服务器向移动设备的用户和用户授权的用户提供服务，但不向其他用户提供服务。 个人服务器可以是移动设备的用户的家庭PC。 个人服务器可以用作向移动设备提供服务的共享服务器的代理服务器。 个人服务器可以在移动设备和共享服务器之间转发消息。 个人服务器可以存储，登录，过滤和对用户的个人数据执行其他处理，诸如由移动设备和/或共享服务器发送的消息。 个人服务器可以聚合从多个共享服务器接收的消息。 非个人服务器可以执行附加服务，例如配置个人服务器，并且如果个人服务器变得不可访问，则临时存储数据。

公开(公告)号：US20050227919A1

公开(公告)日：2005-10-13

申请号：US11001474

申请日：2004-11-30

申请人： Alan Ashworth ,  Stephen Jackson ,  Niall Martin ,  Graeme Smith

发明人： Alan Ashworth ,  Stephen Jackson ,  Niall Martin ,  Graeme Smith

IPC分类号： A61K31/00 ,  A61K31/366 ,  A61K31/405 ,  A61K31/4184 ,  A61K31/4706 ,  A61K31/473 ,  A61K31/502 ,  A61K31/517 ,  A61K31/522 ,  A61K31/675 ,  A61K38/54 ,  A61K48/00

CPC分类号： A61K31/366 ,  A61K31/00 ,  A61K31/405 ,  A61K31/4184 ,  A61K31/4706 ,  A61K31/473 ,  A61K31/502 ,  A61K31/517 ,  A61K31/522 ,  A61K31/675 ,  Y02A50/473

摘要： The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.

摘要翻译： 本发明涉及对在HR依赖性DNA DSB修复缺陷的细胞中碱基切除修复途径的抑制选择性致死的认识。 本文提供了使用靶向基础切除修复组分（如PARP）的抑制剂治疗缺乏HR依赖性DNA DSB修复的癌症治疗方法和手段。

公开(公告)号：US08661007B1

公开(公告)日：2014-02-25

申请号：US11961892

申请日：2007-12-20

申请人： Graeme Smith ,  Matt Round ,  Andrew Birkett ,  Elinor Trotter ,  Michael Davidson ,  Gregory Huczynski ,  Jason King ,  Haakon Sorensen ,  Jason Kilar

发明人： Graeme Smith ,  Matt Round ,  Andrew Birkett ,  Elinor Trotter ,  Michael Davidson ,  Gregory Huczynski ,  Jason King ,  Haakon Sorensen ,  Jason Kilar

IPC分类号： G06F7/00 ,  G06F17/30

摘要： A method and system are disclosed for allowing a user to suggest information about content that can be utilized in processing subsequent searches. The suggested information may be different from a fixed set of information about an item, such as keywords, attributes, or characteristics of an item, generally provided by a manufacturer or seller of the item. Users can submit to a service the information that they feel is relevant to the item, such as a brief explanation of relevance and a detailed explanation that would help other users to make a decision about the item. The submitted information may be associated with the item information and stored in a data store and utilized as additional attributes of the item for a search. In addition, when a user requests detail information about an item, the user-submitted information may be displayed to the user.

公开(公告)号：US20130254114A1

公开(公告)日：2013-09-26

申请号：US13428623

申请日：2012-03-23

申请人： Graeme Smith

发明人： Graeme Smith

IPC分类号： G06Q30/06 ,  G06Q20/40

CPC分类号： G06Q30/06 ,  G06Q20/20 ,  G06Q20/201 ,  G06Q20/208 ,  G06Q20/3274 ,  G06Q20/3276 ,  G07G1/0054

摘要： Techniques for network-based self-checkout are provided. A consumer of an establishment uses a mobile app to self-scan barcodes of items for purchase. A running list of the items is maintained by a network shopping manager. The consumer uses the app to purchase the items when desired and the shopping manager sends a code to the app to validate the purchase. When exiting the establishment, the app provides the code to a self-service checkout system and as the customer bags the items, each item is validated against the list without requiring any additional action on the part of the consumer.

摘要翻译： 提供了基于网络的自检功能。 企业的消费者使用移动应用程序自行扫描要购买的物品的条形码。 项目的运行列表由网络购物经理维护。 消费者使用应用程序在需要时购买项目，购物经理将代码发送到应用程序以验证购买。 当退出企业时，应用程序将代码提供给自助结帐系统，并且随着客户包装物品，每个项目都对该列表进行验证，而不需要对消费者进行任何额外的操作。

公开(公告)号：US20070238729A1

公开(公告)日：2007-10-11

申请号：US11758332

申请日：2007-06-05

申请人： Niall Martin ,  Graeme Smith ,  Roger Griffin ,  Bernard Golding ,  Ian Hardcastle ,  David Newell ,  Hilary Calvert ,  Nicola Curtin ,  Laurent Rigoreau ,  Xiao-ling Cockcroft ,  Vincent Junior Loh ,  Paul Workman ,  Florence Raynaud ,  Bernard Nutley

发明人： Niall Martin ,  Graeme Smith ,  Roger Griffin ,  Bernard Golding ,  Ian Hardcastle ,  David Newell ,  Hilary Calvert ,  Nicola Curtin ,  Laurent Rigoreau ,  Xiao-ling Cockcroft ,  Vincent Junior Loh ,  Paul Workman ,  Florence Raynaud ,  Bernard Nutley

IPC分类号： A61K31/351 ,  A61K31/519 ,  A61K31/5377 ,  A61P35/00

CPC分类号： C07D417/04 ,  C07D309/38 ,  C07D311/22 ,  C07D311/92 ,  C07D471/04

摘要： The invention relates to the use of compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, in the preparation of a medicament for inhibiting the activity of DNA-PK, wherein R1 and R2 are independently hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; X and Y are selected from CR4 and O, O and CR′4 and NR″4 and N, where the unsaturation is in the appropriate place in the ring, and where one of R3 and R4 or R′4 is an optionally substituted C3-20 heteroaryl or C5-20 aryl group, and the other of R3 and R4 or R′4 is H, or R3 and R4 or R″4 together are -A-B—, which collectively represent a fused optionally substituted aromatic ring. The compounds also selectively inhibit the activity of DNA-PK compared to PI 3-kinase and/or ATM.

摘要翻译： 本发明涉及式（I）化合物及其异构体，盐，溶剂合物，化学保护形式及其前药在制备用于抑制DNA-PK活性的药物中的用途，其中R 1， R 2和R 2各自独立地为氢，任选取代的C 1-7 - 烷基，C 3-20杂环基或C 或者可以与它们所连接的氮原子一起形成具有4至8个环原子的任选取代的杂环; X和Y选自CR 4和O，O和CR'4和NR“4和N，其中不饱和键处于 R 2中的一个是R 3，R 4，R 4和R 4中的一个是任选取代的C 3 -20个杂芳基或C 5-20-20芳基，R 3和R 4中的另一个或R' > 4 是H，或R 3和R 4或R“4”一起是-AB-，它们共同表示 稠合的任选取代的芳环。 与PI3-激酶和/或ATM相比，化合物还选择性地抑制DNA-PK的活性。

公开(公告)号：US20070049588A1

公开(公告)日：2007-03-01

申请号：US11468315

申请日：2006-08-30

申请人： Graeme Smith ,  Niall Martin ,  Andrew Slade ,  Keith Menear ,  Marc Hummersone ,  Xiao-Ling Cockcroft ,  Ian Matthews ,  Laurent Rigoreau ,  Roger Griffin ,  David Newell ,  Nicola Curtin

发明人： Graeme Smith ,  Niall Martin ,  Andrew Slade ,  Keith Menear ,  Marc Hummersone ,  Xiao-Ling Cockcroft ,  Ian Matthews ,  Laurent Rigoreau ,  Roger Griffin ,  David Newell ,  Nicola Curtin

IPC分类号： A61K31/5377 ,  C07D413/14

CPC分类号： C07D409/04

摘要： A compound of formula (I): and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, and their use in treating diseases ameliorated by the inhibition of ATM.

摘要翻译： 式（I）的化合物及其异构体，盐，溶剂化物，化学保护形式及其前药，以及它们在治疗通过抑制ATM而改善的疾病中的用途。